Mouse OSMR beta PE-conjugated Antibody Summary
Glu24-Leu738
Accession # O70458
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of OSM R beta in D3 Mouse Cell Line by Flow Cytometry. D3 mouse embryonic stem cell line was stained with Rat Anti-Mouse OSM R beta PE-conjugated Monoclonal Antibody (Catalog # FAB662P, filled histogram) or isotype control antibody (IC006P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of OSMR beta in 3T3-L1 cells by Flow Cytometry 3T3-L1 cells were stained with Rat Anti-Mouse OSMR beta PE‑conjugated Monoclonal Antibody (Catalog # FAB662P, filled histogram) or isotype control antibody (Catalog # IC006P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: OSMR beta
Oncostatin M (OSM) is a member of the IL-6 family of cytokines that share the gp130 as a common signal transducing receptor subunit. Human OSM signals through two types of human OSM receptor complexes: the type I complex comprising the leukemia inhibitory factor receptor beta (LIF R beta ) and gp130, the type II complex made up of OSM receptor beta (OSM R beta ) and gp130. In contrast, mouse OSM signals only through the mouse OSM R beta and gp130 complex. Mouse OSM R beta cDNA encodes a 971 amino acid (aa) type I transmembrane protein which contains a 23 aa signal peptide, an extracellular domain of 714 aa, a transmembrane domain of 20 aa and a 214 aa cytoplasmic domain. Mouse OSM R beta alone binds mOSM with low-affinity but forms a high-affinity binding complex in the presence of gp130. Mouse OSM R beta is 55% identical at the amino acid sequence level to human OSM R beta.
- Lindberg, R.A. et al. (1998) Mol. Cell. Biol. 18:3357.
- Tanaka, M. et al. (1999) Blood 93:804.
Product Datasheets
Citations for Mouse OSMR beta PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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CD34+ cell-derived fibroblast-macrophage cross-talk drives limb ischemia recovery through the OSM-ANGPTL signaling axis
Authors: Y Song, J Yang, T Li, X Sun, R Lin, Y He, K Sun, J Han, G Yang, X Li, B Liu, D Yang, G Dang, X Ma, X Du, B Zhang, Y Hu, W Kong, X Wang, H Zhang, Q Xu, J Feng
Science Advances, 2023-04-12;9(15):eadd2632.
Species: Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: IHC, Flow Cytometry -
Murine Oncostatin M Has Opposing Effects on the Proliferation of OP9 Bone Marrow Stromal Cells and NIH/3T3 Fibroblasts Signaling through the OSMR
Authors: Lena Jakob, Tony Andreas Müller, Michael Rassner, Helen Kleinfelder, Pia Veratti, Jan Mitschke et al.
International Journal of Molecular Sciences
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