Mouse SorCS2 Antibody Summary
Ala118-Gly1078
Accession # Q9EPR5
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
SorCS2 in Mouse Brain. SorCS2 was detected in perfusion fixed frozen sections of mouse brain using Sheep Anti-Mouse SorCS2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4237) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
View Larger
SorCS2 in Mouse Brain. SorCS2 was detected in perfusion fixed frozen sections of mouse brain using Sheep Anti-Mouse SorCS2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4237) at 15 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # NL010) and counterstained with DAPI (blue). View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: SorCS2
Mouse SorCS2 is a 110‑130 kDa member of the Vps10p (vacuolar protein sorting 10 protein)-D family of sorting receptors. It is synthesized as a 1159 amino acid (aa) preproprecursor that undergoes proteolytic processing to generate a 1042 aa mature type I transmembrane receptor. The extracellular domain shows an imperfect LRR and a Vps10p domain. SorCS2 is plasma membrane expressed and may undergo proteolytic cleavage. Over aa 118-1078, mouse SorCS2 is 88% and 98% aa identical to human and rat SorCs2, respectively.
Product Datasheets
Citations for Mouse SorCS2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
10
Citations: Showing 1 - 10
Filter your results:
Filter by:
-
The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior
Authors: Joanna I. Giza, Jihye Kim, Heidi C. Meyer, Agustin Anastasia, Iva Dincheva, Crystal I. Zheng et al.
Neuron
-
Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor
Authors: Ayon-Olivas, M;Wolf, D;Andreska, T;Granado, N;Lüningschrör, P;Ip, CW;Moratalla, R;Sendtner, M;
Biology
Species: Mouse
Sample Types: Whole Cells
Applications: Immunocytochemistry -
Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal development
Authors: Skeldal, S;Voss, LF;Lende, J;Pedersen, SB;Mølgaard, S;Ollendorff, MK;Demange, P;Bentsen, AH;Fuglsang, M;Sander, MR;Buttenschøn, H;Gustafsen, C;Madsen, P;Glerup, S;
The Journal of biological chemistry
Species: N/A
Sample Types: Recombinant Protein
Applications: Western Blot -
ProBDNF signaling is involved in periodontitis-induced depression-like behavior in mouse hippocampus
Authors: Y Li, X Guan, Y He, X Jia, L Pan, Y Wang, Y Han, R Zhao, J Yang, T Hou
International immunopharmacology, 2023-02-02;116(0):109767.
Species: Transgenic Mouse
Sample Types: Cell Lysates
Applications: Immunoprecipitation, Western Blot -
SorCS2 is required for social memory and trafficking of the NMDA receptor
Authors: J Yang, Q Ma, I Dincheva, J Giza, D Jing, T Marinic, TA Milner, A Rajadhyaks, FS Lee, BL Hempstead
Mol. Psychiatry, 2020-01-27;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology
Authors: AR Malik, K Szydlowska, K Nizinska, A Asaro, EA van Vliet, O Popp, G Dittmar, R Fritsche-G, JA Kirwan, A Nykjaer, K Lukasiuk, E Aronica, TE Willnow
Cell Rep, 2019-03-05;26(10):2792-2804.e6.
Species: Mouse
Sample Types: Tissue Homogenates, Whole Cells, Whole Tissue
Applications: ICC, IHC, Immunoprecipitation, Western Blot -
Prions amplify through degradation of the VPS10P sorting receptor sortilin
Authors: K Uchiyama, M Tomita, M Yano, J Chida, H Hara, NR Das, A Nykjaer, S Sakaguchi
PLoS Pathog., 2017-06-30;13(6):e1006470.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease
Authors: Q Ma, J Yang, TA Milner, JG Vonsattel, ME Palko, L Tessarollo, BL Hempstead
JCI Insight, 2017-05-04;2(9):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear
Authors: A Forge, RR Taylor, SJ Dawson, M Lovett, DJ Jagger
PLoS Genet, 2017-03-27;13(3):e1006692.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Spatiotemporal patterns of sortilin and SorCS2 localization during organ development
Authors: Simon Boggild, Simon Molgaard, Simon Glerup, Jens Randel Nyengaard
BMC Cell Biology
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Mouse SorCS2 Antibody
There are currently no reviews for this product. Be the first to review Mouse SorCS2 Antibody and earn rewards!
Have you used Mouse SorCS2 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
