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Mouse TIM-1/KIM-1/HAVCR Antibody

Catalog #: AF1817
103 Citations 1 Review Datasheet / COA / SDS
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AF1817
AF1817-SP
Detection of Mouse TIM‑1/KIM‑1/HAVCR by Western Blot.
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Citations (103)
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Mouse TIM-1/KIM-1/HAVCR Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse TIM‑1/KIM-1/HAVCR in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human TIM-1, recombinant mouse (rm) TIM-2, rmTIM-3, rmTIM-4, rmTIM-6, and rmTIM-7 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TIM‑1/KIM-1/HAVCR
Tyr22-Thr212
Accession # NP_001160104
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Mouse TIM‑1/KIM‑1/HAVCR antibody by Western Blot. View Larger

Detection of Mouse TIM‑1/KIM‑1/HAVCR by Western Blot. Western blot shows lysates of NIH-3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse TIM-1/KIM-1/HAVCR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1817) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for TIM-1/KIM-1/HAVCR at approximately 70-80 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Western Blot Detection of Mouse TIM-1/KIM-1/HAVCR by Western Blot View Larger

Detection of Mouse TIM-1/KIM-1/HAVCR by Western Blot Exogenous biological renal support improved renal IRI and decreased mortality and serum Cr, BUN levels in old IRI mice. (A) Survival curves for the old IRI mice at 72 hours. (B) Cr levels in the old mice. (C) BUN levels in the old mice. (D) Representative photographs of kidney sections from the old mice stained with periodic acid–Schiff (400× magnification). (E) Renal tubular injury score. (F) The levels of Kim1 in kidney extracts from the old mice, as measured by western blotting. Gels were performed under the same experimental conditions. (G) Quantitative analyses of the band densities of Kim1 expression. Values are presented as means ± SDs. ▲P < 0.05, ▲▲P < 0.01 vs. O: sham; *P < 0.05, **P < 0.01 vs. O: IRI. BUN, blood urea nitrogen Cr, serum creatinine; SD, standard deviation. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/30978173), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TIM-1/KIM-1/HAVCR

TIM-1 (T cell-immunoglobulin-mucin; also KIM-1 and HAVCR) is a 70-80 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules (1-4). This gene family is involved in the regulation of Th1 and Th2-cell-mediated immunity. In mouse, there are eight known TIM genes (# 1-8) vs. only three genes in human (# 1, 3, and 4) (1, 2). Mouse TIM-1 and -2 are counterparts of human TIM-1 while mouse TIM-5 through 8 have no human counterparts (2). Mouse TIM-1 is synthesized as a 305 amino acid (aa) precursor that contains a 21 aa signal sequence, a 216 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 47 aa cytoplasmic domain (5, 6). The ECD contains one V-type Ig-like domain and a mucin region characterized by multiple T-S-P motifs. The mucin region undergoes extensive O-linked glycosylation. The mouse TIM-1 gene is highly polymorphic and, based on rat, may undergo alternate splicing (4, 6). For instance, HBA mice show a 15 aa deletion in the mucin region that occurs in BALB/c mice (6). This difference is associated with a decreased susceptibility to asthma. Other polymorphisms are also documented (6). In human, TIM-1 is known to circulate as a soluble form. It undergoes constitutive cleavage by an undefined MMP, releasing a 75-85 kDa soluble molecule (5). The same thing might be expected in mouse. The ECD of mouse TIM-1 is 50%, 39%, and 80% aa identical to human, canine and rat TIM-1 ECD, respectively. The only two reported ligands for TIM-1 are TIM-4 and the hepatitis A virus (8, 9). However, others are believed to exist, and based on the ligand for TIM-3, one possibility might be an S-type lectin (10). TIM-1 ligation induces T cell proliferation and promotes cytokine production (1, 10). In particular, it induces IL-4 production, and requires the cytoplasmic tyrosine phosphorylation motif (5).

References
  1. Meyers, J.H. et al. (2005) Trends Mol. Med. 11:1471. 
  2. Kuchroo, V.K. et al. (2003) Nat. Rev. Immunol. 3:454. 
  3. Mariat, C. et al. (2005) Phil. Trans. R. Soc. B 360:1681.  
  4. Ichimura, T. et al. (1998) J. Biol. Chem. 273:4135.  
  5. de Souza, A.J. et al. (2005) Proc. Natl. Acad. Sci. USA 102:17113. 
  6. McIntire, J.J. et al. (2001) Nat. Immunol. 2:1109.
  7. Bailly, V. et al. (2002) J. Biol. Chem. 277:39739.
  8. Feigelstock, D. et al. (1998) J. Virol. 72:6621.
  9. Zhu, C. et al. (2005) Nat. Immunol. 6:1245.
  10. Meyers, J.H. et al. (2005) Nat. Immunol. 6:455.
Long Name
T Cell Immunoglobulin Mucin-1
Entrez Gene IDs
26762 (Human); 171283 (Mouse); 286934 (Rat); 102141332 (Cynomolgus Monkey)
Alternate Names
CD365; HAVCR1; HAVCR-1; HAVCRT cell immunoglobin domain and mucin domain protein 1; hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM1; KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1; TIM1; TIM-1; TIM-1TIM; TIM1TIMD-1; TIMD1T-cell membrane protein 1

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Citations for Mouse TIM-1/KIM-1/HAVCR Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

103 Citations: Showing 1 - 10
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  1. Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition
    Authors: L Xu, J Guo, DG Moledina, LG Cantley
    Nature Communications, 2022-08-19;13(1):4892.
  2. KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.
    Authors: Brooks C, Yeung M, Brooks Y, Chen H, Ichimura T, Henderson J, Bonventre J
    EMBO J, 2015-08-17;34(19):2441-64.
  3. Macrophage autophagy protects against acute kidney injury by inhibiting renal inflammation through the degradation of TARM1
    Authors: Huang, XR;Ye, L;An, N;Wu, CY;Wu, HL;Li, HY;Huang, YH;Ye, QR;Liu, MD;Yang, LW;Liu, JX;Tang, JX;Pan, QJ;Wang, P;Sun, L;Xia, Y;Lan, HY;Yang, C;Liu, HF;
    Autophagy
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: Immunohistochemistry, Western Blot
  4. Remote organ cancer adversely alters renal function and induces kidney injury, inflammation, and fibrosis
    Authors: Hammouri, D;Orwick, A;Doll, M;Vega, DS;Shah, PP;Clarke, CJ;Clem, B;Beverly, LJ;Siskind, LJ;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  5. Injury-induced FoxM1 expression in mouse kidney drives epithelial proliferation by a Cyclin F dependent mechanism
    Authors: Noonan, ML;Muto, Y;Yoshimura, Y;Leckie-Harre, A;Wu, H;Kalinichenko, VV;Humphreys, BD;Chang-Panesso, M;
    JCI insight
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  6. A Tripeptide (Ser-Arg-Pro, SRP) from Sipunculus nudus L. Improves Cadmium-Induced Acute Kidney Injury by Targeting the MAPK, Inflammatory, and Apoptosis Pathways in Mice
    Authors: Pan, Y;Peng, Z;Fang, Z;Iddrisu, L;Sun, L;Deng, Q;Gooneratne, R;
    Marine drugs
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  7. Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction
    Authors: Wang, P;Ouyang, J;Zhou, K;Hu, D;Zhang, S;Zhang, A;Yang, Y;
    Biomedical journal
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  8. Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury
    Authors: Vlasschaert, C;Robinson-Cohen, C;Chen, J;Akwo, E;Parker, AC;Silver, SA;Bhatraju, PK;Poisner, H;Cao, S;Jiang, M;Wang, Y;Niu, A;Siew, E;Van Amburg, JC;Kramer, HJ;Kottgen, A;Franceschini, N;Psaty, BM;Tracy, RP;Alonso, A;Arking, DE;Coresh, J;Ballantyne, CM;Boerwinkle, E;Grams, M;Zhang, MZ;Kestenbaum, B;Lanktree, MB;Rauh, MJ;Harris, RC;Bick, AG;
    Nature medicine
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  9. JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway
    Authors: Li, Z;He, R;Liu, J;Jin, X;Jiang, B;Lao, Y;Yang, S;
    BMC complementary medicine and therapies
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  10. High resolution spatial profiling of kidney injury and repair using RNA hybridization-based in situ sequencing
    Authors: Wu, H;Dixon, EE;Xuanyuan, Q;Guo, J;Yoshimura, Y;Debashish, C;Niesnerova, A;Xu, H;Rouault, M;Humphreys, BD;
    Nature communications
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  11. Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury
    Authors: Diaz-Bulnes, P;Rodríguez, RM;Banon-Maneus, E;Saiz, ML;Bernet, CR;Corte-Iglesias, V;Ramirez-Bajo, MJ;Lazo-Rodriguez, M;Tamargo-Gómez, I;Rodrigues-Diez, RR;Sanz, AB;Diaz-Corte, C;Ruiz-Ortega, M;Diekmann, F;Aransay, AM;Lopez-Larrea, C;Suarez-Alvarez, B;
    International journal of biological sciences
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  12. Integrin ?1-rich extracellular vesicles of kidney recruit Fn1+ macrophages to aggravate ischemia-reperfusion-induced inflammation
    Authors: Wang, W;Ren, X;Chen, X;Hong, Q;Cai, G;
    JCI insight
    Species: Human, Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  13. MicroRNA-26a alleviates tubulointerstitial fibrosis in diabetic kidney disease by targeting PAR4
    Authors: Qu, G;Li, X;Jin, R;Guan, D;Ji, J;Li, S;Shi, H;Tong, P;Gan, W;Zhang, A;
    Journal of cellular and molecular medicine
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  14. Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells
    Authors: Cai, F;Li, D;Xie, Y;Wang, X;Ma, H;Xu, H;Cheng, J;Zhuang, H;Hua, ZC;
    Redox biology
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  15. Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway
    Authors: Jin, X;He, R;Lin, Y;Liu, J;Wang, Y;Li, Z;Liao, Y;Yang, S;
    Drug design, development and therapy
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  16. DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK
    Authors: Shi, L;Zha, H;Pan, Z;Wang, J;Xia, Y;Li, H;Huang, H;Yue, R;Song, Z;Zhu, J;
    Cell death & disease
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. Reciprocal regulation between the molecular clock and kidney injury
    Authors: Carlos Rey-Serra, Jessica Tituaña, Terry Lin, J Ignacio Herrero, Verónica Miguel, Coral Barbas et al.
    Life Science Alliance
  18. TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy
    Authors: Yu, B;Jin, L;Yao, X;Zhang, Y;Zhang, G;Wang, F;Su, X;Fang, Q;Xiao, L;Yang, Y;Jiang, LH;Chen, J;Yang, W;Lin, W;Han, F;
    Theranostics
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: IHC, ICC
  19. WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury
    Authors: Deng, Z;Wang, Y;Liu, J;Zhang, H;Zhou, L;Zhao, H;Han, Y;Yan, S;Dong, Z;Wang, Y;Dai, Y;Deng, F;
    Redox biology
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  20. Clonal Hematopoiesis of Indeterminate Potential is Associated with Acute Kidney Injury
    Authors: Vlasschaert, C;Robinson-Cohen, C;Kestenbaum, B;Silver, SA;Chen, JC;Akwo, E;Bhatraju, PK;Zhang, MZ;Cao, S;Jiang, M;Wang, Y;Niu, A;Siew, E;Kramer, HJ;Kottgen, A;Franceschini, N;Psaty, BM;Tracy, RP;Alonso, A;Arking, DE;Coresh, J;Ballantyne, CM;Boerwinkle, E;Grams, M;Lanktree, MB;Rauh, MJ;Harris, RC;Bick, AG;
    medRxiv : the preprint server for health sciences
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  21. PFKFB3 mediates tubular cell death in cisplatin nephrotoxicity by activating CDK4
    Authors: Lu Wen, Qingqing Wei, Man J. Livingston, Guie Dong, Siyao Li, Xiaoru Hu et al.
    Translational Research
  22. Fibroblast Growth Factor 2 Is Produced By Renal Tubular Cells to Act as a Paracrine Factor in Maladaptive Kidney Repair After Cisplatin Nephrotoxicity
    Authors: Hu X, Ma Z, Li S et al.
    Laboratory Investigation
  23. Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner
    Authors: K Hoeft, GJL Schaefer, H Kim, D Schumacher, T Bleckwehl, Q Long, BM Klinkhamme, F Peisker, L Koch, J Nagai, M Halder, S Ziegler, E Liehn, C Kuppe, J Kranz, S Menzel, I Costa, A Wahida, P Boor, RK Schneider, S Hayat, R Kramann
    Cell Reports, 2023-02-17;42(2):112131.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  24. Cytoplasmic HMGB1 induces renal tubular ferroptosis after ischemia/reperfusion
    Authors: Z Zhao, G Li, Y Wang, Y Li, H Xu, W Liu, W Hao, Y Yao, R Zeng
    International immunopharmacology, 2023-02-01;116(0):109757.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  25. Pifithrin-alpha ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation
    Authors: Chen Yuqiang, Zhang Lisha, Wen Jiejun, Xue Qin, Wang Niansong
    Renal Failure
  26. Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation
    Authors: Kensei Taguchi, Bertha C. Elias, Sho Sugahara, Snehal Sant, Benjamin S. Freedman, Sushrut S. Waikar et al.
    Journal of Clinical Investigation
  27. Chromatin accessibility dynamics dictate renal tubular epithelial cell response to injury
    Authors: X Cao, J Wang, T Zhang, Z Liu, L Liu, Y Chen, Z Li, Y Zhao, Q Yu, T Liu, J Nie, Y Niu, Y Chen, L Yang, L Zhang
    Nature Communications, 2022-11-28;13(1):7322.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  28. Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice
    Authors: Kenneth R. Hallows, Hui Li, Biagio Saitta, Saman Sepehr, Polly Huang, Jessica Pham et al.
    Frontiers in Molecular Biosciences
  29. Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair
    Authors: S Ide, K Ide, K Abe, Y Kobayashi, H Kitai, J McKey, SA Strausser, LL O'Brien, A Tata, PR Tata, T Souma
    Cell Reports, 2022-11-08;41(6):111610.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  30. Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway
    Authors: Banghua Zhang, Shanshan Wan, Hao Liu, Qiangmin Qiu, Hui Chen, Zhiyuan Chen et al.
    Oxidative Medicine and Cellular Longevity
  31. Rice Endosperm Protein Improves the Anti-Inflammatory Effects of High-Density Lipoprotein and Produces Lower Atherosclerotic Lesion Accelerated by the Renal Mass Reduction than Casein in a Mouse Model
    Authors: Ryohei Kaseda, Michihiro Hosojima, Shoji Kuwahara, Hideyuki Kabasawa, Hiroyuki Aoki, Yuki Higuchi et al.
    Journal of the American Nutrition Association
  32. Functional consequence of myeloid ferritin heavy chain on acute and chronic effects of rhabdomyolysis-induced kidney injury
    Authors: Kayla R. McCullough, Juheb Akhter, Mauhaun J. Taheri, Amie Traylor, Anna A. Zmijewska, Vivek Verma et al.
    Frontiers in Medicine
  33. Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections
    Authors: Yizhuo Wang, Shuyun Liu, Lan Li, Ling Li, Xueli Zhou, Meihua Wan et al.
    Journal of Controlled Release
  34. EPO synthesis induced by HIF‐PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non‐injured nephron segments in murine kidney fibrosis
    Authors: Hanako Kobayashi, Olena Davidoff, Shiuli Pujari‐Palmer, Malin Drevin, Volker H. Haase
    Acta Physiol (Oxf)
  35. Does G Protein-Coupled Estrogen Receptor 1 Contribute to Cisplatin-Induced Acute Kidney Injury in Male Mice?
    Authors: Eman Y. Gohar, Rawan N. Almutlaq, Chunlan Fan, Rohan S. Balkawade, Maryam K. Butt, Lisa M. Curtis
    International Journal of Molecular Sciences
  36. Nephroprotective Effects of Semaglutide as Mono- and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease
    Authors: LS Dalbøge, M Christense, MR Madsen, T Secher, N Endlich, V Drenic', A Manresa-Ar, HH Hansen, I Rune, LN Fink, MV Østergaard
    Biomedicines, 2022-07-11;10(7):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  37. Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies
    Authors: Haojia Wu, Romer Gonzalez Gonzalez Villalobos, Xiang Yao, Dermot Reilly, Tao Chen, Matthew Rankin et al.
    Cell Metabolism
  38. Regulation of renal calbindin expression during cisplatin‐induced kidney injury
    Authors: Blessy George, John T. Szilagyi, Melanie S. Joy, Lauren M. Aleksunes
    Journal of Biochemical and Molecular Toxicology
  39. Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis
    Authors: MJ Livingston, S Shu, Y Fan, Z Li, Q Jiao, XM Yin, MA Venkatacha, Z Dong
    Autophagy, 2022-05-18;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes
    Authors: Albert Pérez-Martí, Suresh Ramakrishnan, Jiayi Li, Aurelien Dugourd, Martijn R Molenaar, Luigi R De La Motte et al.
    eLife
  41. Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway
    Authors: Chen XC, Wu D, Wu HL et al.
    Lupus Science & Medicine
  42. Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy
    Authors: T Eckes, S Patyna, A Koch, A Oftring, S Gauer, N Obermüller, S Schwalm, L Schaefer, J Chun, HJ Gröne, J Pfeilschif
    International Journal of Molecular Sciences, 2022-04-02;23(7):.
    Species: Mouse
    Sample Types: Tissue Lysates
    Applications: Western Blot
  43. Quantitative Super-Resolution Microscopy Reveals Promoting Mitochondrial Interconnectivity Protects against AKI
    Authors: Kensei Taguchi, Bertha C. Elias, Evan Krystofiak, Subo Qian, Snehal Sant, Haichun Yang et al.
    Kidney360
  44. Snapshots of nascent RNA reveal cell- and stimulus- specific responses to acute kidney injury
    Authors: TH Shen, J Stauber, K Xu, A Jacunski, N Paragas, M Callahan, R Banlengchi, AD Levitman, B Desanti de, A Beenken, MS Grau, E Mathieu, Q Zhang, Y Li, T Gopal, N Askanase, S Arumugam, S Mohan, PI Good, JS Stevens, F Lin, SK Sia, CS Lin, V D'Agati, K Kiryluk, NP Tatonetti, J Barasch
    JCI Insight, 2022-03-22;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  45. Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis
    Authors: Kensuke Sasaki, Andrew S. Terker, Jiaqi Tang, Shirong Cao, Juan Pablo Arroyo, Aolei Niu et al.
    JCI Insight
  46. Hepatitis A Virus Cellular Receptor 1 (HAVcr-1) Initiates Prostate Cancer Progression in Human Cells via Hepatocyte Growth Factor (HGF)-Induced Changes in Junctional Integrity
    Authors: EA Telford, AJ Sanders, S Owen, F Ruge, GM Harrison, WG Jiang, TA Martin
    Biomolecules, 2022-02-21;12(2):.
    Species: Human
    Sample Types: Protein
    Applications: Western Blot
  47. Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy
    Authors: S Wang, K Jing, H Wu, X Li, C Yang, T Li, H Tang, T Zou, Y She, HF Liu
    Oxidative Medicine and Cellular Longevity, 2022-01-12;2022(0):2812493.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  48. Hydroxychloroquine administration exacerbates acute kidney injury complicated by lupus nephritis
    Authors: N An, C Yang, HL Wu, Y Guo, XJ Huang, TS Huang, ZH Wu, J Xue, RH Chen, ZH Li, QJ Pan, HF Liu
    Arthritis Research & Therapy, 2022-01-03;24(1):6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  49. Loss of renal olfactory receptor 1393 leads to improved glucose homeostasis in a type 1 diabetic mouse model
    Authors: AR Schiazza, EG Considine, M Betcher, BD Shepard
    Physiological Reports, 2021-12-01;9(23):e15007.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  50. Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
    Authors: L Mulderrig, JI Garaycoech, ZK Tuong, CL Millington, FA Dingler, JR Ferdinand, L Gaul, JA Tadross, MJ Arends, S O'Rahilly, GP Crossan, MR Clatworthy, KJ Patel
    Nature, 2021-11-24;600(7887):158-163.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  51. Farrerol Ameliorated Cisplatin-Induced Chronic Kidney Disease Through Mitophagy Induction via Nrf2/PINK1 Pathway
    Authors: N Ma, Z Wei, J Hu, W Gu, X Ci
    Frontiers in Pharmacology, 2021-11-11;12(0):768700.
    Species: Mouse, Transgenic Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  52. Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice
    Authors: Ranea-Robles P, Portman K, Bender A et al.
    Kidney360
  53. Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy
    Authors: YK You, WF Wu, XR Huang, HD Li, YP Ren, JC Zeng, H Chen, HY Lan
    International journal of biological sciences, 2021-09-21;17(14):3911-3922.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  54. Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair
    Authors: Shintaro Ide, Yoshihiko Kobayashi, Kana Ide, Sarah A Strausser, Koki Abe, Savannah Herbek et al.
    eLife
  55. Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma
    Authors: JC Lee, DM Yotis, JY Lee, MA Sarabusky, B Shrum, A Champagne, OZ Ismail, E Tutunea-Fa, HS Leong, L Gunaratnam
    Scientific Reports, 2021-06-04;11(1):11840.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  56. Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis
    Authors: Verónica Miguel, Jessica Tituaña, J. Ignacio Herrero, Laura Herrero, Dolors Serra, Paula Cuevas et al.
    Journal of Clinical Investigation
  57. Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition
    Authors: Danielle E. Soranno, Lara Kirkbride-Romeo, Sara A. Wennersten, Kathy Ding, Maria A. Cavasin, Peter Baker et al.
    JACC: Basic to Translational Science
  58. Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity
    Authors: M Arita, S Watanabe, N Aoki, S Kuwahara, R Suzuki, S Goto, Y Abe, M Takahashi, M Sato, S Hokari, A Ohtsubo, S Shoji, K Nozaki, K Ichikawa, R Kondo, M Hayashi, Y Ohshima, H Kabasawa, M Hosojima, T Koya, A Saito, T Kikuchi
    Scientific Reports, 2021-01-12;11(1):750.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  59. The sodium-glucose cotransporter 2 inhibitor tofogliflozin prevents diabetic kidney disease progression in type 2 diabetic mice
    Authors: Z Li, M Murakoshi, S Ichikawa, T Koshida, E Adachi, C Suzuki, S Ueda, T Gohda, Y Suzuki
    FEBS Open Bio, 2020-11-10;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  60. Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality
    Authors: David Legouis, Sven-Erick Ricksten, Anna Faivre, Thomas Verissimo, Karim Gariani, Charles Verney et al.
    Nature Metabolism
  61. Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration
    Authors: R Uni, T Inoue, Y Nakamura, D Fukaya, S Hasegawa, CH Wu, R Fujii, B Suratticha, W Peerapanya, A Ozeki, N Akimitsu, Y Wada, M Nangaku, R Inagi
    Sci Rep, 2020-06-11;10(1):9472.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  62. Signaling pathways predisposing to chronic kidney disease progression
    Authors: M Zaidan, M Burtin, JD Zhang, T Blanc, P Barre, S Garbay, C Nguyen, F Vasseur, L Yammine, S Germano, L Badi, MC Gubler, M Gallazzini, G Friedlande, M Pontoglio, F Terzi
    JCI Insight, 2020-05-07;5(9):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  63. Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy
    Authors: Barbara Mara Klinkhammer, Sonja Djudjaj, Uta Kunter, Runolfur Palsson, Vidar Orn Edvardsson, Thorsten Wiech et al.
    Journal of the American Society of Nephrology
  64. Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury
    Authors: Jing Liu, Sanjeev Kumar, Andreas Heinzel, Michael Gao, Jinjin Guo, Gregory F. Alvarado et al.
    Journal of the American Society of Nephrology
  65. Phenformin Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice without Affecting Immune Cell Infiltration
    Authors: MØ Nørgård, M Christense, H A M Mutsae, R Nørregaard
    Pharmaceutics, 2020-03-26;12(4):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  66. Romidepsin (FK228) in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury is Associated with Down-Regulation of the CYP2E1 Gene
    Authors: Shulin Cheng, Tao Wu, Yugen Li, Jing Huang, Tao Cai
    Medical Science Monitor
  67. FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury
    Authors: M Chang-Pane, FF Kadyrov, M Lalli, H Wu, S Ikeda, E Kefaloyian, MM Abdelmagee, A Herrlich, A Kobayashi, BD Humphreys
    J. Clin. Invest., 2019-12-02;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  68. Metformin modulates immune cell infiltration into the kidney during unilateral ureteral obstruction in mice
    Authors: Michael Christensen, Mikkel Ø. Nørgård, Michael S. Jensen, Bjarne K. Møller, Rikke Nørregaard
    Physiological Reports
  69. Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury
    Authors: WZ Ying, X Li, S Rangarajan, W Feng, LM Curtis, PW Sanders
    J. Clin. Invest., 2019-06-17;129(7):2792-2806.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  70. Inhibition of fibronectin polymerization alleviates kidney injury due to ischemia-reperfusion
    Authors: Stephanie L. K. Bowers, Stephanie Davis-Rodriguez, Zachary M. Thomas, Valeria Rudomanova, W. Clark Bacon, Alex Beiersdorfer et al.
    American Journal of Physiology-Renal Physiology
  71. Gene deletion of the Na+-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion
    Authors: Josselin Nespoux, Rohit Patel, Kelly L. Hudkins, Winnie Huang, Brent Freeman, Young Chul Kim et al.
    American Journal of Physiology-Renal Physiology
  72. Exogenous biological renal support ameliorates renal pathology after ischemia reperfusion injury in elderly mice
    Authors: Dong Liu, Zhiwei Yin, Qi Huang, Yi Ren, Diangeng Li, Linna Wang et al.
    Aging (Albany NY)
  73. Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury
    Authors: C Suzuki, I Tanida, M Ohmuraya, JA Oliva Trej, S Kakuta, T Sunabori, Y Uchiyama
    Int J Mol Sci, 2019-04-05;20(7):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  74. Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury
    Authors: M Zhao, Y Zhou, S Liu, L Li, Y Chen, J Cheng, Y Lu, J Liu
    Drug Deliv, 2018-11-01;25(1):546-554.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  75. Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury
    Authors: Bing Yang, Shanshan Lan, Mélanie Dieudé, Jean-Paul Sabo-Vatasescu, Annie Karakeussian-Rimbaud, Julie Turgeon et al.
    Journal of the American Society of Nephrology
  76. Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
    Authors: E Lazzeri, ML Angelotti, A Peired, C Conte, JA Marschner, L Maggi, B Mazzinghi, D Lombardi, ME Melica, S Nardi, E Ronconi, A Sisti, G Antonelli, F Becherucci, L De Chiara, RR Guevara, A Burger, B Schaefer, F Annunziato, HJ Anders, L Lasagni, P Romagnani
    Nat Commun, 2018-04-09;9(1):1344.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  77. Novel differences in renal gene expression in a diet-induced obesity model
    Authors: Victoria L. Halperin Kuhns, Jennifer L. Pluznick
    American Journal of Physiology-Renal Physiology
  78. Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy
    Authors: O Maydan, PG McDade, Y Liu, XR Wu, DG Matsell, AA Eddy
    Physiol Rep, 2018-03-01;6(6):e13654.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  79. PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against Renal ischemia-reperfusion injury
    Authors: C Tang, H Han, M Yan, S Zhu, J Liu, Z Liu, L He, J Tan, Y Liu, H Liu, L Sun, S Duan, Y Peng, F Liu, XM Yin, Z Zhang, Z Dong
    Autophagy, 2018-02-17;0(0):1-45.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  80. Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease
    Authors: Y Kim, SJ Park, SR Manson, CA Molina, K Kidd, H Thiessen-P, RJ Perry, H Liapis, S Kmoch, CR Parikh, AJ Bleyer, YM Chen
    JCI Insight, 2017-12-07;2(23):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  81. Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion
    Authors: J Liu, S Kumar, E Dolzhenko, GF Alvarado, J Guo, C Lu, Y Chen, M Li, MC Dessing, RK Parvez, PE Cippà, AM Krautzberg, G Saribekyan, AD Smith, AP McMahon
    JCI Insight, 2017-09-21;2(18):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  82. Unique sex- and age-dependent effects in protective pathways in acute kidney injury
    Authors: Ravindra Boddu, Chunlan Fan, Sunil Rangarajan, Bhuvana Sunil, Subhashini Bolisetty, Lisa M. Curtis
    American Journal of Physiology-Renal Physiology
  83. Forkhead Box O3 (FoxO3) Regulates Kidney Tubular Autophagy Following Urinary Tract Obstruction
    Authors: L Li, R Zviti, C Ha, ZV Wang, JA Hill, F Lin
    J. Biol. Chem., 2017-07-13;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  84. Cytoresistance after acute kidney injury is limited to the recovery period of proximal tubule integrity and possibly involves Hippo-YAP signaling
    Authors: Takamasa Iwakura, Yoshihide Fujigaki, Tomoyuki Fujikura, Takayuki Tsuji, Naro Ohashi, Akihiko Kato et al.
    Physiological Reports
  85. Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity
    Authors: Yoshihisa Hori, Nobumasa Aoki, Shoji Kuwahara, Michihiro Hosojima, Ryohei Kaseda, Sawako Goto et al.
    Journal of the American Society of Nephrology
  86. 15-Deoxy-delta 12,14-prostaglandin J2 Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction
    Authors: Line Nilsson, Fredrik Palm, Rikke Nørregaard
    Mediators of Inflammation
  87. Gli1+ Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury
    Authors: Rafael Kramann, Janewit Wongboonsin, Monica Chang-Panesso, Flavia G. Machado, Benjamin D. Humphreys
    Journal of the American Society of Nephrology
  88. Rescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3?
    Sci Rep, 2016-11-18;6(0):36698.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  89. Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor ? Coactivator-1? by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions
    Authors: JB Collier, RM Whitaker, ST Eblen, RG Schnellman
    J. Biol. Chem., 2016-11-14;291(52):26850-26859.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  90. GDF11 improves tubular regeneration after acute kidney injury in elderly mice
    Authors: Ying Zhang, Qinggang Li, Dong Liu, Qi Huang, Guangyan Cai, Shaoyuan Cui et al.
    Scientific Reports
  91. Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury
    Sci Rep, 2016-09-07;6(0):32610.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  92. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage
    Authors: Takehiro Suzuki, Hiroaki Yamaguchi, Motoi Kikusato, Osamu Hashizume, Satoru Nagatoishi, Akihiro Matsuo et al.
    Journal of the American Society of Nephrology
  93. Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure
    Authors: Prasad R. Konkalmatt, Laureano D. Asico, Yanrong Zhang, Yu Yang, Cinthia Drachenberg, Xiaoxu Zheng et al.
    JCI Insight
  94. High-resolution renal perfusion mapping using contrast-enhanced ultrasonography in ischemia-reperfusion injury monitors changes in renal microperfusion
    Authors: Krisztina Fischer, F. Can Meral, Yongzhi Zhang, Mark G. Vangel, Ferenc A. Jolesz, Takaharu Ichimura et al.
    Kidney International
  95. Kidney Injury Molecule-1 Enhances Endocytosis of Albumin in Renal Proximal Tubular Cells
    Authors: Xueying Zhao, Chen Jiang, Rebecca Olufade, Dong Liu, Nerimiah Emmett
    Journal of Cellular Physiology
  96. Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk
    Authors: Omar H. Maarouf, Anusha Aravamudhan, Deepika Rangarajan, Tetsuro Kusaba, Victor Zhang, Jeremy Welborn et al.
    Journal of the American Society of Nephrology
  97. Kidney-specific Sonoporation-mediated Gene Transfer.
    Authors: Ishida R, Kami D, Kusaba T, Kirita Y, Kishida T, Mazda O, Adachi T, Gojo S
    Mol Ther, 2015-09-30;24(1):125-34.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  98. Characterizing functional domains for TIM-mediated enveloped virus entry.
    Authors: Moller-Tank S, Albritton L, Rennert P, Maury W
    J Virol, 2014-04-02;88(12):6702-13.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  99. Kielin/Chordin-Like Protein Attenuates both Acute and Chronic Renal Injury
    Authors: Abdul Soofi, Peng Zhang, Gregory R. Dressler
    Journal of the American Society of Nephrology
  100. Long-term rescue of dystrophin expression and improvement in muscle pathology and function in dystrophic mdx mice by peptide-conjugated morpholino.
    Am. J. Pathol., 2012-06-07;181(2):392-400.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  101. Repair of injured proximal tubule does not involve specialized progenitors.
    Authors: Humphreys BD, Czerniak S, DiRocco DP
    Proc. Natl. Acad. Sci. U.S.A., 2011-05-16;108(22):9226-31.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  102. TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.
    Authors: Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, DeKruyff RH, Saito H, Galli SJ
    Blood, 2007-07-09;110(7):2565-8.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  103. Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions
    Authors: Suzuki C, Tanida I, Oliva Trejo JA, et al.
    Int J Mol Sci

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Mouse TIM-1/KIM-1/HAVCR Antibody
By Anonymous on 12/02/2016
Application: WB Sample Tested: Kidney tissue (cortex) Species: Mouse
Western Blot Mouse TIM-1/KIM-1/HAVCR Antibody AF1817