Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit Summary
Product Summary
Precision
Cell Culture Supernates, Serum
Intra-Assay Precision | Inter-Assay Precision | |||||
---|---|---|---|---|---|---|
Sample | 1 | 2 | 3 | 1 | 2 | 3 |
n | 20 | 20 | 20 | 20 | 20 | 20 |
Mean (pg/mL) | 99 | 261 | 830 | 111 | 285 | 886 |
Standard Deviation | 8 | 6.8 | 18.3 | 8.8 | 17.8 | 57.8 |
CV% | 8.1 | 2.6 | 2.2 | 7.9 | 6.2 | 6.5 |
Recovery
The recovery of mouse TRANCE spiked to three levels throughout the range of the assay in various matrices was evaluated.
Sample Type | Average % Recovery | Range % |
---|---|---|
Cell Culture Supernates (n=6) | 99 | 87-116 |
Serum (n=6) | 93 | 80-104 |
Linearity
Scientific Data
Product Datasheets
Preparation and Storage
Background: TRANCE/TNFSF11/RANK L
TRANCE (TNF-related activation-induced cytokines), also known as RANK Ligand, OPGL, or ODF, is a TNF superfamily ligand produced by osteoblasts, bone marrow stromal cells, and activated T cells. It signals through RANK and is antagonized by the decoy receptor Osteoprotegerin. TRANCE stimulates bone resorption, is required for osteoclast differentiation, and is associated with the development of osteoporosis, vascular calcification, osteopetrosis, and progestin-induced breast cancer. It also mediates body temperature regulation and is essential for the development of a lactating mammary gland.
Assay Procedure
Refer to the product- Prepare all reagents, standard dilutions, and samples as directed in the product insert.
- Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
- Add 50 µL of Assay Diluent to each well.
- Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
- Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.
- Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
- Aspirate and wash 5 times.
- Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.
- Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
Citations for Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling
Authors: Uehara, N;Shibusawa, N;Mikami, Y;Kyumoto-Nakamura, Y;Sonoda, S;Kato, H;Yamaza, T;Kukita, T;
Archives of biochemistry and biophysics
Species: Mouse
Sample Types: Cell Culture Supernates
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Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to Pagetic lesion formation
Authors: Miyagawa, K;Tenshin, H;Mulcrone, PL;Delgado-Calle, J;Subler, MA;Windle, JJ;Chirgwin, JM;Roodman, GD;Kurihara, N;
JCI insight
Species: Mouse
Sample Types: Serum
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MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair
Authors: X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard
International Journal of Molecular Sciences, 2023-01-25;24(3):.
Species: Mouse
Sample Types: Serum
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Increased UHMWPE Particle-Induced Osteolysis in Fetuin-A-Deficient Mice
Authors: C Polan, C Brenner, M Herten, G Hilken, F Grabellus, HL Meyer, M Burggraf, M Dudda, W Jahnen-Dec, C Wedemeyer, MD Kauther
Journal of functional biomaterials, 2023-01-04;14(1):.
Species: Mouse
Sample Types: Serum
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MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair
Authors: X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard
International Journal of Molecular Sciences, 2023;24(3):.
Species: Mouse
Sample Types: Serum
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Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes
Authors: JM Kim, YS Yang, J Xie, O Lee, J Kim, J Hong, B Boldyreff, O Filhol, H Chun, MB Greenblatt, G Gao, JH Shim
Cell Death and Differentiation, 2022-02-15;0(0):.
Species: Mouse
Sample Types: Serum
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Increased bone resorption by long-term cigarette smoke exposure in animal model
Authors: JJM Junqueira, JD Lourenço, KR da Silva, V Jorgetti, RP Vieira, AA de Araujo, K De Angelis, AT Correia, LHV Alves, IFLC Tibério, AP Barbosa, FDTQDS Lopes
Heliyon, 2021-12-10;7(12):e08587.
Species: Mouse
Sample Types: Tissue Homogenates
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Osteoblast-specific inactivation of p53 results in locally increased bone formation
Authors: N Liao, T Koehne, J Tuckermann, I Triviai, M Amling, JP David, T Schinke, J Luther
PLoS ONE, 2021-11-18;16(11):e0249894.
Species: Mouse
Sample Types: Serum
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Decreased Trabecular Bone Mass in Col22a1-Deficient Mice
Authors: W Zhao, P Wiedemann, EM Wölfel, M Neven, S Peters, T Imhof, M Koch, B Busse, M Amling, T Schinke, TA Yorgan
Cells, 2021-11-04;10(11):.
Species: Mouse
Sample Types: Serum
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Hydroxycoumarin Scopoletin Inhibits Bone Loss through Enhancing Induction of Bone Turnover Markers in a Mouse Model of Type 2 Diabetes
Authors: EJ Lee, W Na, MK Kang, YH Kim, DY Kim, H Oh, SI Kim, SY Oh, S Park, K Park, YH Kang
Biomedicines, 2021-06-07;9(6):.
Species: Mouse
Sample Types: Plasma
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Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo
Authors: RS MacLeod, MB Meyer, J Xiong, KM Cawley, Y Liu, M Onal, NA Benkusky, JD Thostenson, JW Pike, CA O'Brien
PLoS ONE, 2021-05-10;16(5):e0250974.
Species: Mouse, Transgenic Mouse
Sample Types: Serum
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The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis
Authors: M Timmen, H Hidding, M Götte, TE Khassawna, D Kronenberg, R Stange
Sci Rep, 2020-11-25;10(1):20510.
Species: Mouse
Sample Types: Cell Culture Supernates
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Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption
Authors: KM Cawley, NC Bustamante, AG Guha, RS MacLeod, J Xiong, I Gubrij, Y Liu, R Mulkey, M Palmieri, JD Thostenson, JJ Goellner, CA O'Brien
Cell Rep, 2020-09-08;32(10):108052.
Species: Mouse
Sample Types: Serum
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Glucose transporter 4 mediates LPS-induced IL-6 production in osteoblasts under high glucose conditions
Authors: S Kato, N Tanabe, M Nagao, J Sekino, K Tomita, M Sakai, K Abe, N Suzuki, K Ueda
J Oral Sci, 2020-08-31;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Sclerostin expression in trabecular bone is downregulated by osteoclasts
Authors: M Koide, T Yamashita, K Murakami, S Uehara, K Nakamura, M Nakamura, M Matsushita, T Ara, H Yasuda, JM Penninger, N Takahashi, N Udagawa, Y Kobayashi
Sci Rep, 2020-08-13;10(1):13751.
Species: Mouse
Sample Types: Serum
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Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin
Authors: T Velletri, Y Huang, Y Wang, Q Li, M Hu, N Xie, Q Yang, X Chen, Q Chen, P Shou, Y Gan, E Candi, AP Margherita, M Agostini, H Yang, G Melino, Y Shi, Y Wang
Cell Death Differ., 2020-07-21;0(0):.
Species: Mouse
Sample Types: Serum
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Abaloparatide exhibits greater osteoanabolic response and higher cAMP stimulation and beta-arrestin recruitment than teriparatide
Authors: K Sahbani, CP Cardozo, WA Bauman, HA Tawfeek
Physiol Rep, 2019-10-01;7(19):e14225.
Species: Mouse
Sample Types: Serum
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Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase
Authors: T Heckt, LJ Brylka, M Neven, M Amling, T Schinke
PLoS ONE, 2019-07-17;14(7):e0219734.
Species: Mouse
Sample Types: Serum
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Human Enriched Serum Following Hydrolysed Collagen Absorption Modulates Bone Cell Activity: from Bedside to Bench and Vice Versa
Authors: F Wauquier, A Daneault, H Granel, J Prawitt, V Fabien Sou, J Berger, B Pereira, J Guicheux, GY Rochefort, N Meunier, A Blot, Y Wittrant
Nutrients, 2019-05-31;11(6):.
Species: Mouse
Sample Types: Serum
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Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration
Authors: X Gao, A Lu, Y Tang, J Schneppend, AB Liebowitz, AC Scibetta, ER Morris, H Cheng, C Huard, S Amra, B Wang, MA Hall, WR Lowe, J Huard
Stem Cell Res Ther, 2018-11-21;9(1):316.
Species: Mouse
Sample Types: Serum
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Coupling of bone resorption and formation by RANKL reverse signalling
Authors: Y Ikebuchi, S Aoki, M Honma, M Hayashi, Y Sugamori, M Khan, Y Kariya, G Kato, Y Tabata, JM Penninger, N Udagawa, K Aoki, H Suzuki
Nature, 2018-09-05;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
Authors: J Xiong, K Cawley, M Piemontese, Y Fujiwara, H Zhao, JJ Goellner, CA O'Brien
Nat Commun, 2018-07-25;9(1):2909.
Species: Mouse
Sample Types: Plasma
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Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim)
Authors: SM Zimmerman, ME Heard-Lips, M Dimori, JD Thostenson, EM Mannen, CA O'Brien, R Morello
Bone Rep, 2018-07-02;9(0):61-73.
Species: Mouse
Sample Types: Bone Marrow Fluid
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New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment
Authors: LC Cheung, J Tickner, AM Hughes, P Skut, M Howlett, B Foley, J Oommen, JE Wells, B He, S Singh, GA Chua, J Ford, CG Mullighan, RS Kotecha, UR Kees
Leukemia, 2018-05-08;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Central RANK signalling in NPY neurons alters bone mass in male mice
Authors: NJ Lee, IM Clarke, RF Enriquez, V Nagy, J Penninger, PA Baldock, H Herzog
Neuropeptides, 2018-02-15;0(0):.
Species: Mouse
Sample Types: Serum
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Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss
Authors: N Yang, B Baban, CM Isales, XM Shi
PLoS ONE, 2017-08-03;12(8):e0181133.
Species: Mouse
Sample Types: Serum
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Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2
Authors: OJ Park, J Kim, J Yang, CH Yun, SH Han
J. Bone Miner. Res, 2017-04-27;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging
Authors: HM Davis, R Pacheco-Co, EG Atkinson, LR Brun, AR Gortazar, J Harris, M Hiasa, SA Bolarinwa, T Yoneda, M Ivan, A Bruzzaniti, T Bellido, LI Plotkin
Aging Cell, 2017-03-19;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Silicon Nitride: A Synthetic Mineral for Vertebrate Biology
Sci Rep, 2016-08-19;6(0):31717.
Species: Human
Sample Types: Cell Culture Supernates
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Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-kappaB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts.
Authors: Kassem A, Henning P, Lundberg P, Souza P, Lindholm C, Lerner U
J Biol Chem, 2015-06-17;290(33):20147-58.
Species: Mouse
Sample Types: Tissue Homogenates
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The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway.
Authors: Yang Y, Blair H, Shapiro I, Wang B
J Biol Chem, 2015-05-15;290(27):16918-28.
Species: Mouse
Sample Types: Cell Culture Supernates
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A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse.
Authors: Onal M, Bishop K, St John H, Danielson A, Riley E, Piemontese M, Xiong J, Goellner J, O'Brien C, Pike J
J Bone Miner Res, 2015-05-01;30(5):855-68.
Species: Mouse
Sample Types: Serum
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5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.
Authors: Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino M, Akira S
J Biol Chem, 2015-02-17;290(15):9377-86.
Species: Mouse
Sample Types: Serum
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Aconitum pseudo-laeve var. erectum inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis via the c-Fos/nuclear factor of activated T-cells, cytoplasmic 1 signaling pathway and prevents lipopolysaccharide-induced bone loss in mice.
Authors: Baek, Jong Min, Kim, Ju-Young, Cheon, Yoon-Hee, Park, Sun-Hyan, Ahn, Sung-Jun, Yoon, Kwon-Ha, Oh, Jaemin, Lee, Myeung S
Molecules, 2014-08-05;19(8):11628-44.
Species: Mouse
Sample Types: Serum
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Inhibition of bone remodeling in young mice by bisphosphonate displaces the plasma cell niche into the spleen.
Authors: Teufel S, Grotsch B, Luther J, Derer A, Schinke T, Amling M, Schett G, Mielenz D, David J
J Immunol, 2014-06-04;193(1):223-33.
Species: Mouse
Sample Types: Serum
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Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL.
Authors: Ohba T, Cole H, Cates J, Slosky D, Haro H, Ando T, Schwartz H, Schoenecker J
J Bone Miner Res, 2014-06-01;29(6):1431-45.
Species: Mouse
Sample Types: Cell Culture Supernates
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Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.
Authors: Teramachi J, Zhou H, Subler M, Kitagawa Y, Galson D, Dempster D, Windle J, Kurihara N, Roodman G
J Bone Miner Res, 2014-06-01;29(6):1456-65.
Species: Mouse
Sample Types: Cell Culture Supernates
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Effects of neuropeptides and mechanical loading on bone cell resorption in vitro.
Authors: Yoo Y, Kwag J, Kim K, Kim C
Int J Mol Sci, 2014-04-08;15(4):5874-83.
Species: Mouse
Sample Types: Cell Culture Supernates
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Effects of the peroxisome proliferator-activated receptor (PPAR)-delta agonist GW501516 on bone and muscle in ovariectomized rats.
Authors: Mosti M, Stunes A, Ericsson M, Pullisaar H, Reseland J, Shabestari M, Eriksen E, Syversen U
Endocrinology, 2014-04-07;155(6):2178-89.
Species: Rat
Sample Types: Plasma
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Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis.
Authors: Gruenwald K, Castagnola P, Besio R, Dimori M, Chen Y, Akel N, Swain F, Skinner R, Eyre D, Gaddy D, Suva L, Morello R
J Bone Miner Res, 2014-03-01;29(3):666-75.
Species: Mouse
Sample Types: Serum
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Autophagy in osteoblasts is involved in mineralization and bone homeostasis.
Authors: Nollet M, Santucci-Darmanin S, Breuil V, Al-Sahlanee R, Cros C, Topi M, Momier D, Samson M, Pagnotta S, Cailleteau L, Battaglia S, Farlay D, Dacquin R, Barois N, Jurdic P, Boivin G, Heymann D, Lafont F, Lu S, Dempster D, Carle G, Pierrefite-Carle V
Autophagy, 2014-01-01;10(11):1965-77.
Species: Mouse
Sample Types: Tissue Culture Supernates
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Resolvin E1 and chemokine-like receptor 1 mediate bone preservation.
Authors: Gao L, Faibish D, Fredman G, Herrera B, Chiang N, Serhan C, Van Dyke T, Gyurko R
J Immunol, 2012-12-14;190(2):689-94.
Species: Mouse
Sample Types: Cell Culture Supernates
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Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma.
Authors: Buckle, Clive He, De Leenheer, Evy, Lawson, Michelle, Yong, Kwee, Rabin, Neil, Perry, Mark, Vanderkerken, Karen, Croucher, Peter Ia
PLoS ONE, 2012-08-29;7(8):e41127.
Species: Mouse
Sample Types: Serum
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Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss.
Authors: Onal M, Xiong J, Chen X, Thostenson J, Almeida M, Manolagas S
Oncogene, 2012-07-10;287(35):29851-60.
Species: Mouse
Sample Types: Cell Culture Supernates
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Osteoprotection by semaphorin 3A.
Authors: Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H
Nature, 2012-05-03;485(7396):69-74.
Species: Mouse
Sample Types: Serum
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Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway.
Authors: Ma B, Zhang Q, Wu D, Wang YL, Hu YY, Cheng YP, Yang ZD, Zheng YY, Ying HJ
Acta Pharmacol. Sin., 2012-03-19;33(4):479-89.
Species: Rat
Sample Types: Serum
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The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice.
Authors: Onal M, Galli C, Fu Q, Xiong J, Weinstein RS, Manolagas SC, O'Brien CA
Mol. Endocrinol., 2011-12-29;26(2):341-8.
Species: Mouse
Sample Types: Plasma
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Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans.
Authors: Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, Pierroz D, Morandi L, De Simone M, Rucci N, Bertini E, Bianchi ML, De Benedetti F, Teti A
J. Bone Miner. Res., 2011-08-01;26(8):1891-903.
Species: Mouse
Sample Types: Serum
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C17 prevents inflammatory arthritis and associated joint destruction in mice.
Authors: Chao C, Joyce-Shaikh B, Grein J
PLoS ONE, 2011-07-25;6(7):e22256.
Species: Mouse
Sample Types: Serum
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Effects of relaxin and estrogens on bone remodeling markers, receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG), in rat adjuvant-induced arthritis.
Authors: Ho TY, Santora K, Chen JC, Frankshun AL, Bagnell CA
Bone, 2011-03-16;48(6):1346-53.
Species: Rat
Sample Types: Plasma
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Functional characterization of a novel mutation localized in the start codon of the tissue-nonspecific alkaline phosphatase gene.
Authors: Mentrup B, Marschall C, Barvencik F, Amling M, Plendl H, Jakob F, Beck C
Bone, 2011-03-16;48(6):1401-8.
Species: Rat
Sample Types: Plasma
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Systemic effects of ulna loading in male rats during functional adaptation.
Authors: Sample SJ, Collins RJ, Wilson AP, Racette MA, Behan M, Markel MD, Kalscheur VL, Hao Z, Muir P
J. Bone Miner. Res., 2010-09-01;25(9):2016-28.
Species: Rat
Sample Types: Plasma
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Increased trabecular bone formation in mice lacking the growth factor midkine.
Authors: Neunaber C, Catala-Lehnen P, Beil FT
J. Bone Miner. Res., 2010-08-01;25(8):1724-35.
Species: Mouse
Sample Types: Serum
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ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.
Authors: Sauer AV, Mrak E, Hernandez RJ, Zacchi E, Cavani F, Casiraghi M, Grunebaum E, Roifman CM, Cervi MC, Ambrosi A, Carlucci F, Roncarolo MG, Villa A, Rubinacci A, Aiuti A
Blood, 2009-07-24;114(15):3216-26.
Species: Mouse
Sample Types: Serum
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Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome.
Authors: O'Connor RD, Zayzafoon M, Farach-Carson MC, Schanen NC
Bone, 2009-05-03;45(2):346-56.
Species: Mouse
Sample Types: Serum
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Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.
Authors: Pierroz DD, Rufo A, Bianchi EN, Glatt V, Capulli M, Rucci N, Cavat F, Rizzoli R, Teti A, Bouxsein ML, Ferrari SL
J. Bone Miner. Res., 2009-05-01;24(5):775-84.
Species: Mouse
Sample Types: Cell Culture Supernates
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Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro.
Authors: Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS
Bone, 2009-04-18;45(2):309-20.
Species: Mouse
Sample Types: Cell Culture Supernates
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Overexpression of bone sialoprotein leads to an uncoupling of bone formation and bone resorption in mice.
Authors: Valverde P, Zhang J, Fix A, Zhu J, Ma W, Tu Q, Chen J
J. Bone Miner. Res., 2008-11-01;23(11):1775-88.
Species: Mouse
Sample Types: Serum
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Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.
Authors: Qiang YW, Chen Y, Stephens O, Brown N, Chen B, Epstein J, Barlogie B, Shaughnessy JD
Blood, 2008-02-27;112(1):196-207.
Species: Human, Mouse
Sample Types: Cell Culture Supernates
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Comparison of the effects of genistein and zoledronic acid on the bone loss in OPG-deficient mice.
Authors: Liu J, Xu K, Wen G, Guo H, Li S, Wu X, Dai R, Sheng Z, Liao E
Bone, 2008-02-08;42(5):950-9.
Species: Mouse
Sample Types: Serum
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The essential role of IFN-gamma in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice.
Authors: Garlet GP, Cardoso CR, Campanelli AP, Garlet TP, Avila-Campos MJ, Cunha FQ, Silva JS
Microbes Infect., 2008-01-25;10(5):489-96.
Species: Mouse
Sample Types: Tissue Homogenates
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Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.
Authors: Morony S, Tintut Y, Zhang Z, Cattley RC, Van G, Dwyer D, Stolina M, Kostenuik PJ, Demer LL
Circulation, 2008-01-02;117(3):411-20.
Species: Mouse
Sample Types: Plasma
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Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction.
Authors: Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N
J. Immunol., 2007-07-01;179(1):639-46.
Species: Mouse
Sample Types: Cell Culture Supernates
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Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
Authors: Brechter AB, Lerner UH
Arthritis Rheum., 2007-03-01;56(3):910-23.
Species: Mouse
Sample Types: Whole Tissue
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B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo.
Authors: Li Y, Toraldo G, Li A, Yang X, Zhang H, Qian WP, Weitzmann MN
Blood, 2007-01-03;109(9):3839-48.
Species: Mouse
Sample Types: Cell Culture Supernates
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Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts.
Authors: Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, Mizoguchi T, Sato M, Mogi M, Penninger JM, Takahashi N
J. Immunol., 2007-01-01;178(1):192-200.
Species: Mouse
Sample Types: Serum
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Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice.
Authors: Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL, Fu WM
J. Biol. Chem., 2006-11-10;282(4):2346-54.
Species: Mouse
Sample Types: Cell Culture Supernates
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New 19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 analogs strongly stimulate osteoclast formation both in vivo and in vitro.
Authors: Sato M, Nakamichi Y, Nakamura M, Sato N, Ninomiya T, Muto A, Nakamura H, Ozawa H, Iwasaki Y, Kobayashi E, Shimizu M, DeLuca HF, Takahashi N, Udagawa N
Bone, 2006-10-25;40(2):293-304.
Species: Mouse
Sample Types: Serum
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Performed using normal mouse mammary tissue lysates.