Mouse TREML4/TLT-4 Biotinylated Antibody

Catalog #: BAF5500 Datasheet / COA / SDS

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BAF5500

All TREML4/TLT-4 Antibodies

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Mouse TREML4/TLT-4 Biotinylated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse TREML4/TLT‑4 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human TREM1, recombinant mouse (rm) TREM2b, and rmTREM3 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse TREML4/TLT‑4
Ser25-Val195
Accession # NP_001029094

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Mouse TREML4/TLT‑4

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TREML4/TLT-4

TREML4 (Triggering receptor expressed on myeloid cells-like 4; also TLT4) is a 29 kDa (predicted) member of the Ig superfamily. It is likely expressed by leukocytes and based on its structure, may act as an activating receptor. Mature mouse TREML4 is a type I transmembrane (TM) protein 235 amino acids (aa) in length. It contains a 171 aa extracellular region (aa 29‑199) with a V-type Ig-like domain (aa 29‑122); the TM segment contains one Lys residue. There is one splice variant that shows a deletion of aa 21‑24, a segment that lies in the putative signal sequence. Rodent and human TREML4 are highly divergent and thus over aa 25‑195, mouse TREML4 shares 78% aa identity with rat TREML4, but only 52% aa identity with human TREML4.

Long Name

Triggering Receptor Expressed on Myeloid Cells-like 4

Entrez Gene IDs

285852 (Human); 224840 (Mouse); 680862 (Rat)

Alternate Names

TLT4; TREML4