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MPD 2

Catalog #: 8802 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8802/5
MPD 2 | Active Degraders
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Description: SARS-CoV-2 Mpro Degrader (PROTAC®)

Chemical Name: 3-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)oxy)benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

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Biological Activity

MPD 2 is a SARS-CoV-2 Mpro Degrader (PROTAC®) (DC50 = 296 nM in 293T cells). Mpro degradation is time-dependent and CRBN-mediated. Antiviral in A549-ACE2 cells infected with several SARS-CoV-2 strains (EC50 = 492 nM at delta variant) and against a nirmatrelvir-resistant mutant of SARS-CoV-2, NSP5 E166A (EC50 = 460 nM).

Scientific Data

Western Blot Application of MPD 2 View Larger

Application of MPD 2. Western blot data showing dose responsive degradation with MPD 2 on transiently expressed SARS-CoV-2 Main Protease in HEK293 cells. 1st Ab: HRP Anti-V5 tag antibody [E10/V4RR] (ab173837) (1:2000), 2nd Ab: Anti-Mouse HRP (1:5000). Loading control: 1st Ab: Anti-alpha - Tubulin antibody [DM1A] - (1:10000) 2nd Ab: Anti-mouse HRP (1:5000). Data provided by Brönstrup Lab at the Helmholtz Centre for Infection Research.

Technical Data

M.Wt:
973.13
Formula:
C51H68N6O13
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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