Home / Adenosine A2b Receptor Antagonists / MRS 1754

MRS 1754

Catalog #: 2752
16 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2752/10
MRS 1754 | CAS No. 264622-58-4 | Adenosine A2b Receptor Antagonists
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Description: Selective A2B antagonist

Chemical Name: N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide

Purity: ≥98%

Product Details
Citations (16)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

MRS 1754 is a selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).

Technical Data

M.Wt:
486.52
Formula:
C26H26N6O4
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
264622-58-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the University of Virginia Patent Foundation

Background References

  1. Ability of ?? T cells to modulate the Foxp3 T cell response is dependent on adenosine
    D Liang, JI Woo, H Shao, WK Born, RL O'Brien, HJ Kaplan, D Sun
    PLoS ONE, 2018;13(5):e0197189.
  2. IFN-gamma Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response.
    Cohen H, Ward A, Hamidzadeh K, Ravid K, Mosser D
    J Immunol, 2015;195(8):3828-37.
  3. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
    He W, Mazumder A, Wilder T, Cronstein B
    FASEB J, 2013;27(9):3446-54.
  4. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors.
    Kim et al.
    J.Med.Chem., 2000;43:1165
  5. [3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors.
    Ji et al.
    Biochem.Pharmacol., 2001;61:657
  6. Adenosine receptor activation ameliorates type I diabetes.
    Nemeth et al.
    FASEB J., 2007;21:2380

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Citations for MRS 1754

The citations listed below are publications that use Tocris products. Selected citations for MRS 1754 include:

16 Citations: Showing 1 - 10

  1. Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.
    Authors: Liu Et al.
    Brain Res  2018;1700:47
  2. Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome.
    Authors: Asano
    Scientific Reports  2017;7:40214
  3. An Adenosine Receptor for Olfaction in Fish.
    Authors: Wakisaka Et al.
    Curr Biol  2017;27:1437
  4. Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
    Authors: Ledderose Et al.
    Purinergic Signalling  2016;
  5. Anti-inflammatory effects of adenosine N1-oxide.
    Authors: Kohno Et al.
    Am J Physiol Lung Cell Mol Physiol  2015;12:2
  6. Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain.
    Authors: Lemos Et al.
    Purinergic Signal  2015;11:561
  7. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
    Authors: Welihinda and Amento
    J Inflamm (Lond)  2014;11:37
  8. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
    Authors: He Et al.
    FASEB J  2013;27:3446
  9. Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum.
    Authors: Garção Et al.
    Br J Pharmacol  2013;169:1600
  10. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Authors: Kan Et al.
    J Virol  2012;86:10338

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