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MRS 2365

Catalog #: 2157
11 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2157/1
MRS 2365 | P2Y Receptor Agonists
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Description: Highly potent and selective P2Y1 agonist

Chemical Name: [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt

Purity: ≥98%

Product Details
Citations (11)
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Biological Activity

MRS 2365 is a highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS.

Technical Data

M.Wt:
549.28
Formula:
C13H16N5O9P2SNa3
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the NIH, US Patent 10/169975

Product Datasheets

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Citations for MRS 2365

The citations listed below are publications that use Tocris products. Selected citations for MRS 2365 include:

11 Citations: Showing 1 - 10

  1. P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development.
    Authors: Zhang Et al.
    Front Cell Neurosci  2019;13:152
  2. Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex.
    Authors: Koch Et al.
    J Cereb Blood Flow Metab  2015;40:305
  3. RASA3 is a critical inhibitor of RAP1-dependent platelet activation.
    Authors: Stefanini Et al.
    J Neurosci  2015;125:1419
  4. Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles.
    Authors: Kurahashi Et al.
    Am J Physiol Cell Physiol  2014;307:C561
  5. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    J Cereb Blood Flow Metab  2013;9:31
  6. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    Neuropsychopharmacology  2013;305:F396
  7. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  8. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia.
    Authors: Kuboyama Et al.
    J Clin Invest  2011;31:1930
  9. Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors.
    Authors: Chandaka Et al.
    Br J Pharmacol  2011;164:1522
  10. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons.
    Authors: Filippov Et al.
    Pharmacol Res  2010;30:11068

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