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MS 159

Catalog #: 8079 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8079/5
MS 159 | CAS No. 3031353-59-7 | Active Degraders
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Description: NSD2 Degrader (PROTAC®)

Chemical Name: N-Cyclopropyl-N-(4-((5-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)propoxy)pyridin-2-yl)-carbamoyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide

Purity: ≥98%

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Biological Activity

MS 159 is a nuclear receptor binding SET structural domain protein 2 (NSD2) Degrader (DC50 = 5.2 μM, Dmax = >82%). Also degrades IKZF3 and IKZF1. Comprises an NSD2 binding moiety joined by a linker to a cereblon E3 ligase ligand. Inhibits proliferation of KMS11 and H929 tumor cells. Bioavailable in vivo.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
828.84
Formula:
C43H40N8O10
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
3031353-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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