Home / Active Degraders / MS 28

MS 28

Catalog #: 8076 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8076/5
MS 28 | CAS No. 2229974-73-4 | Active Degraders
1 Image
Description: Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC®)

Chemical Name: (2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

MS 28 is a cyclinD1 Degrader (PROTAC®) (DC50 = 950 nM; Dmax = 90% in vitro). Also degrades CDK4, CDK6 and cyclin D3 after 4 hours. Degrades cyclin D1 and cyclin D3 by recruiting the CDK4/6 as a 'bridge'. Comprises a CDK4/6 binding moiety joined by a linker to a VHL ligand. Suppresses NCI-H2110 and Calu-1 cancer cell growth at 1 μM.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1002.25
Formula:
C53H67N11O7S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2229974-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Icahn School of Medicine at Mount Sinai.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for MS 28

There are currently no reviews for this product. Be the first to review MS 28 and earn rewards!

Have you used MS 28?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.