MTEP hydrochloride
Chemical Name: 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
Purity: ≥99%
Biological Activity
MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki= 16 nM). Displays anxiolytic activity in vivo and is orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice.
Bradbury et al.
J.Pharmacol.Exp.Ther., 2005;313:395 -
5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
Roppe et al.
Bioorg.Med.Chem.Lett., 2004;14:3993 -
Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABAA signaling.
Klodzinska et al.
Neuropharmacology, 2004;47:342 -
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.
Cosford et al.
J.Med.Chem., 2003;46:204 -
Reduced stress-induced hyperthermia in mGluR5 knockout mice.
Brodkin et al.
Eur.J.Neurosci., 2002;16:2241
Product Datasheets
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Citations for MTEP hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for MTEP hydrochloride include:
11 Citations: Showing 1 - 10
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Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.
Authors: Lim Et al.
Int J Mol Sci 2018;19
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Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
Authors: Thomson Et al.
Neuron 2017;95:550
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The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates.
Authors: Guimaraes Et al.
Cell Death Dis 2015;8:24
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Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
Authors: Rosa Et al.
Mol Brain 2015;4
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Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement.
Authors: Reissner Et al.
Elife 2015;20:316
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Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.
Authors: Arsenault Et al.
PLoS One 2015;10:e0142093
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Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.
Authors: Pollard Et al.
J Psychopharmacol 2014;28:935
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Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus.
Authors: Jurgens Et al.
PLoS One 2012;7:e45717
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Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model.
Authors: Ren Et al.
Anesthesiology 2012;116:122
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Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation.
Authors: Sumislawski Et al.
Neuropsychopharmacology 2011;36:2750
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Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
Authors: Tronson Et al.
Addict Biol 2010;68:1007
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