Nateglinide

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.
   Kroeze et al.
   Nat.Struct.Mol.Biol., 2015;22:362
2. N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of hypoglycemic agents.
   Shinkai et al.
   J.Med.Chem., 1989;32:1436
3. The ability of a new hypoglycemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca²⁺ in pancreatic beta-cells under metabolic inhibition.
   Fujitani et al.
   Br.J.Pharmacol., 1997;120:1191
4. Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and β-cell K_ATP channels.
   Hu et al.
   J.Pharmacol.Exp.Ther., 1999;291:1372
5. Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic β-cell-type K_ATP channels.
   Chachin et al.
   J.Pharmacol.Exp.Ther., 2003;304:1025

Product Datasheets