Home / ARF GTPase Inhibitors / NAV 2729

NAV 2729

Catalog #: 5986
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5986/10
5986/50
NAV 2729 | CAS No. 419547-11-8 | ARF GTPase Inhibitors
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Description: Selective ARF6 inhibitor

Chemical Name: 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NAV 2729 is a selective ARF6 inhibitor (IC50 = 1.0 μM). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.

Technical Data

M.Wt:
456.88
Formula:
C25H17ClN4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
419547-11-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma.
    Yoo et al.
    Cancer Cell., 2016;29:889
  2. Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
    BT Finicle, KH Eckenstein, AS Revenko, BA Anderson, WB Wan, AN McCracken, D Gil, DA Fruman, S Hanessian, PP Seth, AL Edinger
    Nucleic Acids Research, 2023;0(0):.

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Citations for NAV 2729

The citations listed below are publications that use Tocris products. Selected citations for NAV 2729 include:

5 Citations: Showing 1 - 5

  1. Pharmacological Inhibition of Lipid Import and Transport Proteins in Ovarian Cancer.
    Authors: Renate Et al.
    Cancers (Basel)  2022;14
  2. Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.
    Authors: Karlheinz Et al.
    Front Immunol  2020;11:1789
  3. Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1.
    Authors: Ernst Et al.
    Blood Cancer J  2019;9:6
  4. Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency.
    Authors: Gavin Y Et al.
    Circ Res  2019;125:969-988
  5. Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.
    Authors: Finicle Et al.
    J Cell Sci  2018;131

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