NBI 27914 hydrochloride
Chemical Name: 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Purity: ≥99%
Biological Activity
NBI 27914 hydrochloride is a selective, non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonist (Ki = 1.7 nM); has no activity at CRF2 receptors. Blocks behavioral seizures in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists.
Chen et al.
J.Med.Chem., 1996;39:4358 -
Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications.
McCarthy et al.
Curr.Pharm.Des., 1999;5:289 -
The CRF1 receptor mediates the excitatory actions of cortico. releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist.
Baram et al.
Brain Res., 1997;770:89
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Citations for NBI 27914 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NBI 27914 hydrochloride include:
12 Citations: Showing 1 - 10
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Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
Authors: Navarro Et al.
Stroke 2015;35:6639
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Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala NE Systems that Promote PTSD-Like Startle Abnormalities.
Authors: Rajbhandari Et al.
J Neurosci 2015;35:14270
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Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses.
Authors: Ji Et al.
Mol Pain 2013;9:2
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Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
Authors: Silberman and Winder
Neuropharmacology 2013;70:316
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Role of nesfatin-1 in a rat model of visceral hypersensitivity.
Authors: Jia Et al.
Cereb Cortex 2013;19:3487
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Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice.
Authors: Lowery-Gionta Et al.
J Neurosci 2012;32:3405
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CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice.
Authors: Wang Et al.
PLoS One 2011;6:e16377
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NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.
Authors: Delawary Et al.
Mol Brain 2010;3:37
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Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon.
Authors: Liu Et al.
Br J Pharmacol 2010;159:222
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Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.
Authors: Nakamura and Sapru
Am J Physiol Heart Circ Physiol 2009;296:H2022
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Expression, binding, and signaling properties of CRF2(a) receptors endogenously expressed in human retinoblastoma Y79 cells: passage-dependent regulation of functional receptors.
Authors: Gutknecht Et al.
J Neurochem 2008;104:926
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Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex.
Authors: Gallopin Et al.
J Neurosci 2006;16:1440
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