NBI 35965 hydrochloride
Chemical Name: (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride
Purity: ≥98%
Biological Activity
NBI 35965 hydrochloride is a potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki values are 4 and > 10000 nM at CRF1 and CRF2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats.
Million et al.
Brain Res., 2003;985:32 -
Mechanism of corticotropin-releasing factor type I receptor regulation by non-peptide antagonists.
Hoare et al.
Mol.Pharmacol., 2003;63:751 -
Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists.
Gross et al.
J.Med.Chem., 2005;48:5780
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Citations for NBI 35965 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NBI 35965 hydrochloride include:
2 Citations: Showing 1 - 2
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Corticotropin-Releasing Factor Receptors Modulate OXT Release in the Dorsolateral Bed Nucleus of the Stria Terminalis (BNST) in Male Rats.
Authors: Martinon and Dabrowska
Front Neurosci 2018;12:183
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Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors.
Authors: Abdelhamid Et al.
Neuropharmacology 2013;72:29
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