NBMPR
Chemical Name: 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
Purity: ≥99%
Biological Activity
NBMPR is an equilibrative nucleoside transporter 1 (ENT1) inhibitor (Ki values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.
Mandapathil M, Szczepanski M, Harasymczuk M, Ren J, Cheng D, Jackson E, Gorelik E, Johnson J, Lang S, Whiteside T
Oncoimmunology, 2012;1(5):659-669. -
Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells.
Ward et al.
J.Biol.Chem., 2000;275:8375 -
Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer.
Tsujie et al.
Anticancer Res., 2007;27:2241 -
Synthesis and flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors.
Lin and Buolamwini
J.Med.Chem., 2007;50:3906
Product Datasheets
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Citations for NBMPR
The citations listed below are publications that use Tocris products. Selected citations for NBMPR include:
5 Citations: Showing 1 - 5
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Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
Authors: Ahwazi Et al.
Biochem J 2021;478:2977
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Physiology and effects of nucleosides in mice lacking all four adenosine receptors.
Authors: Xiao Et al.
PLoS Biol 2019;17:e3000161
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Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.
Authors: Aungraheeta Et al.
Blood 2016;128:2717
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The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
Authors: Baron Et al.
J Exp Bot 2015;6:e1629
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Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine.
Authors: Clasadonte Et al.
J Neurosci 2014;34:1879
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