NCT 501 hydrochloride
Chemical Name: 8-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-1H-purine-2,6-dione hydrochloride
Purity: ≥98%
Biological Activity
NCT 501 hydrochloride is a potent and selective ALDH1A1 inhibitor (IC50 = 40 nM). Exhibits >1000-fold selectivity for ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2, HPGD and HSD17β4. Also selective over a panel of 168 GPCRs. Blood-brain barrier permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of NCT-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1).
Yang et al.
J.Med.Chem., 2015;58:5967
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Citation for NCT 501 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NCT 501 hydrochloride include:
1 Citation: Showing 1 - 1
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Phenotypic landscape of intestinal organoid regeneration.
Authors: Rui Et al.
Nature 2020;586:275-280
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