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NCX 466

Catalog #: 4537 Datasheet / COA / SDS

Discontinued Product

4537 has been discontinued.
View all Cyclooxygenase Inhibitors products.
NCX 466 | CAS No. 1262956-64-8 | Cyclooxygenase Inhibitors
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Description: Cyclooxygenase-inhibiting nitric oxide donor

Chemical Name: (αS)-6-Methoxy-α-methyl-2-naphthaleneacetic acid (5S)-5,6-bis(nitrooxy)hexyl ester

Purity: ≥98%

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Biological Activity

NCX 466 is a cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD). Inhibits COX-1 and COX-2 while releasing NO. Demonstrates higher efficacy than naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-β and oxidative stress in a mouse model of bleomycin-induced lung fibrosis. Orally available.

Technical Data

M.Wt:
436.41
Formula:
C20H24N2O9
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1262956-64-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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