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Nebivolol hydrochloride

Catalog #: 3517
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Nebivolol hydrochloride | CAS No. 152520-56-4 | Adrenergic beta-1 Receptor Antagonists
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Description: Highly selective β1-adrenoceptor antagonist

Chemical Name: (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Nebivolol hydrochloride is a highly selective β1-adrenoceptor antagonist (Ki values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β1, 5-HT1A, β2, 5-HT2, α1, H1 and D2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 μM in renal arteries) and displays antihypertensive activity in vivo. GRK/β -arrestin biased agonist at the β2 adrenoceptor.

Technical Data

M.Wt:
441.9
Formula:
C22H25F2NO4.HCl
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
152520-56-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Nebivolol hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Nebivolol hydrochloride include:

1 Citation: Showing 1 - 1

  1. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
    Authors: Littmann Et al.
    Brain Res  2015;355:183

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