NF 023
Chemical Name: 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt
Biological Activity
NF 023 is an a subtype-selective, competitive and reversible P2X1 receptor antagonist. Displays IC50 values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α-subunit of Go/i (EC50 ~300 nM). Also inhibits DNA-binding activity of HMGA2 (IC50 = 10.63 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression.
Fritsche G, Nairz M, Libby S, Fang F, Weiss G
J Leukoc Biol, 2012;92(2):353-9. -
Suramin analogues as subtype-selective G protein inhibitors.
Freissmuth et al.
Mol.Pharmacol., 1996;49:602 -
Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors.
Soto et al.
Neuropharmacology, 1999;38:141 -
The effect of P2 receptor antagonists and ATPase inhibition on sympathetic purinergic neurotransmission in the guinea-pig isolated vas deferens.
Sneddon et al.
Br.J.Pharmacol., 2000;129:1089 -
Novel competitive antagonists for P2 purinoceptors.
Van Rhee et al.
Eur.J.Pharmacol., 1994;268:1 -
Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.
Su et al.
Sci.Rep., 2020;10:18850
Product Datasheets
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Citations for NF 023
The citations listed below are publications that use Tocris products. Selected citations for NF 023 include:
10 Citations: Showing 1 - 10
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Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.
Authors: Su Et al.
Sci Rep 2020;10:18850
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Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors.
Authors: Gao Et al.
Virulence 2018;9:1601
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Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
Authors: Ledderose Et al.
J Infect Dis 2016;213:456
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The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
Authors: Nishimura Et al.
PLoS Pathog 2015;11:e1005184
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The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
Authors: Ren Et al.
Emerg Microbes Infect 2014;3:e62
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Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
Authors: Beckham Et al.
Oncogenesis 2013;2:e49
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ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
Authors: Manohar Et al.
J Leukoc Biol 2012;92:787
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Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
Authors: Donnelly-Roberts Et al.
Br J Pharmacol 2009;157:1203
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Purinergic and nitrergic junction potential in the human colon.
Authors: Gallego Et al.
Am J Physiol Gastrointest Liver Physiol 2008;295:G522
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Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat.
Authors: Labrakakis Et al.
J Physiol 2003;549:131
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