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NGB 2904

Catalog #: 2635
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2635/10
2635/50
NGB 2904 | CAS No. 189061-11-8 | Dopamine D3 Receptor Antagonists
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Description: Potent and selective D3 antagonist

Chemical Name: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

NGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

Technical Data

M.Wt:
530.92
Formula:
C28H29Cl2N3O.HCl
Solubility:
Soluble to 25 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
189061-11-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for NGB 2904

The citations listed below are publications that use Tocris products. Selected citations for NGB 2904 include:

2 Citations: Showing 1 - 2

  1. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
    Authors: Nagata Et al.
    Sci Rep  2019;9:16438
  2. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and DA D1 receptor pathways in the diet-induced obese rat.
    Authors: Axel Et al.
    Neuropsychopharmacology  2010;35:1464

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