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Nigericin sodium salt

Catalog #: 4312
19 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4312/10
Nigericin sodium salt | CAS No. 28643-80-3 | Ionophores
1 Image
Description: Selective K+ ionophore

Chemical Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt

Product Details
Citations (19)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Nigericin sodium salt is a potassium ionophore; it exchanges K+ for H+ across biological membranes in a similar manner to Valinomycin (Cat. No. 3373). Nigericin stimulates mitochondrial ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.

Technical Data

M.Wt:
746.94
Formula:
C40H67NaO11
Solubility:
Soluble to 100 mM in ethanol
Storage:
Store at -20°C
CAS No:
28643-80-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. P2X7 receptor antagonism prevents IL-1? release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy
    MG Khalafalla, LT Woods, JM Camden, AA Khan, KH Limesand, MJ Petris, L Erb, GA Weisman
    J. Biol. Chem., 2017;0(0):.
  2. Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production
    H Ahn, E Jeon, JC Kim, SG Kang, SI Yoon, HJ Ko, PH Kim, GS Lee
    Sci Rep, 2017;7(1):1314.
  3. The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin.
    Hamidinia et al.
    Biochemistry., 2004;43:15956
  4. Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles.
    Eytan et al.
    J.Biol.Chem., 1990;22:12949

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Citations for Nigericin sodium salt

The citations listed below are publications that use Tocris products. Selected citations for Nigericin sodium salt include:

19 Citations: Showing 1 - 10

  1. IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis.
    Authors: Yuanyuan Et al.
    Cell Death Dis  2023;14:103
  2. Pharmacological inhibition of HDAC6 suppresses xNLRP3 inflammasome-mediated IL-1β release.
    Authors: Bockstiegel Et al.
    Biochem Pharmacol  2023;
  3. Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
    Authors: Songyan Et al.
    Commun Biol  2022;5:47
  4. Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs.
    Authors: Didier Et al.
    MBio  2022;13:e0117822
  5. Single-cell lactate production rate as a measure of glycolysis in endothelial cells.
    Authors: Jun Et al.
    STAR Protoc  2021;2:100807
  6. Selective activation of PFKL suppresses the phagocytic oxidative burst.
    Authors: Matthew Et al.
    Cell  2021;184:4480-4494.e15
  7. Spatiotemporal Quantification of Cytosolic pH in Arabidopsis Pollen Tubes.
    Authors: José A Et al.
    Bio Protoc  2021;11:e4084
  8. NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation.
    Authors: Jeongho Et al.
    Cells  2021;10
  9. Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity
    Authors: Krzesniak Et al.
    Cell Signal  2020;69
  10. Corticosteroids alleviate lipopolysaccharide-induced inflammation and lung injury via inhibiting NLRP3-inflammasome activation.
    Authors: Bao-Xue Et al.
    J Cell Mol Med  2020;24:12716-12725

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