NNMTi
Chemical Name: 5-Amino-1-methylquinolinium iodide
Purity: ≥97%
Biological Activity
NNMTi is a nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.
Neelakantan et al.
Biochem. Pharmacol., 2019;163:481 -
Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase.
Neelakantan et al.
J.Med.Chem., 2017;60:5015
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