NPS 2143 hydrochloride

Key Product Details

Product Description

NPS 2143 hydrochloride is a selective Ca²⁺-sensing receptor antagonist. Blocks increases in cytoplasmic Ca²⁺ concentrations elicited by human Ca²⁺ receptors expressed in HEK293 cells (IC₅₀ = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC₅₀ = 41 nM). Orally active calcilytic compound.

Product Specifications for NPS 2143 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NPS 2143 hydrochloride

The following data is based on the product molecular weight 445.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.25 mL	11.23 mL	22.45 mL
5 mM	0.45 mL	2.25 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.25 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

• Nemeth The search for calcium receptor antagonists (calcilytics). J.Mol.Endocrinol. 2002 PMID: 12200226
• Huang and Breitwieser Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J.Biol.Chem. 2007 PMID: 17284438
• Nemeth Calcilytic compounds: potent and selective Ca²⁺ receptor antagonists that stimulate secretion of parathyroid hormone. J.Pharmacol.Exp.Ther. 2001 PMID: 11561095

Product Documents for NPS 2143 hydrochloride