Home / Group I mGluR Antagonists / NPS 2390

NPS 2390

Catalog #: 4134
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4134/10
4134/50
NPS 2390 | CAS No. 226878-01-9 | Group I mGluR Antagonists
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Description: Group I mGlu antagonist

Chemical Name: N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NPS 2390 is a group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.

Technical Data

M.Wt:
307.39
Formula:
C19H21N3O
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
226878-01-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Calcium-sensing receptor antagonist NPS2390 attenuates neuronal apoptosis though intrinsic pathway following traumatic brain injury in rats
    Z Xue, Z Song, Y Wan, K Wang, L Mo, Y Wang
    Biochem. Biophys. Res. Commun, 2017;0(0):.
  2. Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.
    Mabire et al.
    J.Med.Chem., 2005;48:2134
  3. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
    Lavreysen et al.
    Mol.Pharmacol., 2003;63:1082
  4. Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist.
    van Wagenen et al.
    Abstr.Soc.Neurosci., 2000;:Program No. 618.3.
  5. Li-Dan-He-Ji Improves Infantile Cholestasis Hepatopathy Through Inhibiting Calcium-Sensing Receptor-Mediated Hepatocyte Apoptosis
    H Qin, LL Zhang, XL Xiong, ZX Jiang, CP Xiao, LL Zhang, YJ Wang, YT Wu, YY Qiu, LS Zhou, SQ Yan
    Front Pharmacol, 2020;11(0):156.

Product Datasheets

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Reconstitution Calculator

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Citations for NPS 2390

The citations listed below are publications that use Tocris products. Selected citations for NPS 2390 include:

2 Citations: Showing 1 - 2

  1. Astrocyte Ca 2+-evoked ATP release regulates myelinated axon excitability and conduction speed.
    Authors: Lezmy Et al.
    Science  2021;374:eabh2858
  2. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor.
    Authors: Li Et al.
    Oxid Med Cell Longev  2016;2016:5203801

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