NS 1738

Catalog #: 2995
3 Citations Datasheet / COA / SDS

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NS 1738 | CAS No. 501684-93-1 | Nicotinic (a7) Receptor Modulators

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Description: Positive allosteric modulator of α7 nAChRs; active in vivo

Chemical Name: N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea

Purity: ≥98%

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Product Details

Citations (3)

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Biological Activity

NS 1738 is a selective positive allosteric modulator of α7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α4β2, α3β3 and α1-containing receptors. Displays cognitive-enhancing properties in vivo.

Technical Data

M.Wt:

365.13

Formula:

C₁₄H₉Cl₂F₃N₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at RT

CAS No:

501684-93-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.
Timmermann et al.
J.Pharmacol.Exp.Ther., 2007;323:294
The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.
Freitas et al.
J.Pharmacol.Exp.Ther., 2013;344:264

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Citations for NS 1738

The citations listed below are publications that use Tocris products. Selected citations for NS 1738 include:

3 Citations: Showing 1 - 3

Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo.
Authors: Bali Et al.
Sci Rep 2019;9:9324
The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors.
Authors: Chatzidaki Et al.
Int J Oncol 2015;97:75
Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.
Authors: Chatzidaki Et al.
Neuropharmacology 2015;10:e0125116

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