NS 3623
Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
Purity: ≥99%
Biological Activity
NS 3623 is a KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].
Hansen et al.
Mol.Pharmacol., 2006;70:1319 -
Restoring repolarization in LQT3.
George
Heart Rhythm., 2009;6:107 -
Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.
Hansen et al.
J.Pharmacol.Exp.Ther., 2007;321:996 -
A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials.
Calloe et al.
Biochem.Pharmacol., 2016;108:36
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