NS 3861

Key Product Details

Product Description

NS 3861 is a α3β2 full agonist (EC₅₀ = 1.6 μM). Also α3β4 partial agonist (EC₅₀ = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (K_i values are 0.62, 7.8, 25 and 55 nM respectively).

Product Specifications for NS 3861

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NS 3861

The following data is based on the product molecular weight 400.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.98 mL
5 mM	0.50 mL	2.50 mL	5.00 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Harpsøe Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J.Biol.Chem. 2013 PMID: 23229547

Product Documents for NS 3861