Home / Histone Acetyltransferase Inhibitors / NU 9056

NU 9056

Catalog #: 4903
14 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4903/10
NU 9056 | CAS No. 1450644-28-6 | Histone Acetyltransferase Inhibitors
1 Image
Description: Inhibitor of KAT5 (Tip60)

Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole

Product Details
Citations (14)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.

Technical Data

M.Wt:
232.37
Formula:
C6H4N2S4
Solubility:
Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Storage:
Store at -20°C
CAS No:
1450644-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
    Coffey et al.
    PLoS One, 2012;7:e45539
  2. Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability
    L Li, M Ghorbani, M Weisz-Hubs, J Rousseau, I Thiffault, RE Schnur, C Breen, R Oegema, MM Weiss, Q Waisfisz, S Welner, H Kingston, JA Hills, EM Boon, L Basel-Salm, O Konen, H Goldberg-S, L Bazak, S Tzur, J Jin, X Bi, M Bruccoleri, K McWalter, MT Cho, M Scarano, GB Schaefer, SS Brooks, SS Hughes, KLI van Gassen, JM van Hagen, TK Pandita, PB Agrawal, PM Campeau, XJ Yang
    J. Clin. Invest., 2019;0(0):.

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Citations for NU 9056

The citations listed below are publications that use Tocris products. Selected citations for NU 9056 include:

14 Citations: Showing 1 - 10

  1. Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form.
    Authors: Mirita Et al.
    Nat Commun  2023;14:2095
  2. The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells.
    Authors: Emily M Et al.
    Oncogenesis  2022;11:33
  3. NU9056, a KAT 5 Inhibitor, Treatment Alleviates Brain Dysfunction by Inhibiting NLRP3 Inflammasome Activation, Affecting Gut Microbiota, and Derived Metabolites in LPS-Treated Mice.
    Authors: Lu Et al.
    Front Nutr  2021;8:701760
  4. Butyrate Reprograms Expression of Specific Interferon-Stimulated Genes.
    Authors: Shan-Lu Et al.
    J Virol  2020;94
  5. Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability.
    Authors: Lin Et al.
    J Clin Invest  2020;130:1431-1445
  6. Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes.
    Authors: Anthony Et al.
    Cell Rep  2019;26:3132-3144.e7
  7. PRMT5-mediated regulation of developmental myelination.
    Authors: Scaglione Et al.
    Nat Commun  2018;9:2840
  8. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice.
    Authors: Narkaj Et al.
    Eneuro  2018;5
  9. Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells.
    Authors: Ho Et al.
    Neurochem Res  2018;43:540
  10. Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion.
    Authors: Bakshi Et al.
    Sci Rep  2017;7:3635

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Efficient NU 9056
By Anonymous on 07/25/2023
Species: Mouse

TESTED THE EFFECT OF NU 9056 ON TREATMENT-INDUCED CELL PROLIFERATION IN MOUSE TISSUE. THE TISSUE SECTIONS WERE STAINED WITH KI67 ANTIBODY IN COMBINATION WITH ANTIBODY FOR CELLS OF INTEREST.

Efficient NU 9056 4903
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