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OG-L002

Catalog #: 6244
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6244/25
6244/5
OG-L002 | CAS No. 1357302-64-7 | Histone Demethylase Inhibitors
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Description: Potent LSD1 inhibitor

Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

OG-L002 is a potent LSD1 inhibitor (IC50 = 20 nM). Exhibits some selectivity for LSD1 over MAO-B and MAO-A (IC50 values are 0.72 and 1.38 μM, respectively). Inhibits herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro. Suppresses HSV primary infection in vivo.

Technical Data

M.Wt:
225.29
Formula:
C15H15NO
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol and to 20 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1357302-64-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for OG-L002

The citations listed below are publications that use Tocris products. Selected citations for OG-L002 include:

1 Citation: Showing 1 - 1

  1. Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1.
    Authors: Chris Et al.
    Elife  2020;9

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