Home / Vasopressin Receptor Agonists / OPC 21268

OPC 21268

Catalog #: 3924
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3924/10
3924/50
OPC 21268 | CAS No. 131631-89-5 | Vasopressin Receptor Agonists
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Description: Orally active vasopressin V1 antagonist

Chemical Name: N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

OPC 21268 is a nonpeptide vasopressin V1 receptor antagonist. Displays greater affinity for rat V1 than human V1 (Ki values are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V1 receptors over V2 receptors. Orally active.

Technical Data

M.Wt:
449.54
Formula:
C26H31N3O4
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
131631-89-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for OPC 21268

The citations listed below are publications that use Tocris products. Selected citations for OPC 21268 include:

3 Citations: Showing 1 - 3

  1. Evidence for a Prehypertensive Water Dysregulation Affecting the Development of Hypertension: Results of Very Early Treatment of Vasopressin V1 and V2 Antagonism in Spontaneously Hypertensive Rats.
    Authors: Gallia Et al.
    Front Cardiovasc Med  2022;9:897244
  2. Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908).
    Authors: Harshida Et al.
    J Biol Rhythms  2020;35:340-352
  3. Asymmetric vasopressin signaling spatially organizes the master circadian clock.
    Authors: Amita Et al.
    J Comp Neurol  2018;526:2048-2067

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