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Org 20599

Catalog #: 2738 Datasheet / COA / SDS

Discontinued Product

2738 has been discontinued.
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Org 20599 | CAS No. 156685-94-8 | GABA-A Receptor Modulators
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Description: Positive allosteric modulator of GABAA receptors; direct agonist at higher concentrations

Chemical Name: (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one

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Biological Activity

Org 20599 is a positive allosteric modulator and at higher concentrations direct agonist of GABAA receptors (EC50 = 1.1 μM). Also displays positive modulation of glycine receptors (EC50 = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.

Technical Data

M.Wt:
438.04
Formula:
C25H40ClNO3
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Storage:
Store at RT
CAS No:
156685-94-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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