Org 24598 lithium salt

Name: Org 24598 lithium salt
Brand: Tocris Bioscience
SKU: 4035

Catalog #: 4035 Datasheet / COA / SDS

Newer Version Available: 4447

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Discontinued Product

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Org 24598 lithium salt | CAS No. 722456-08-8 | Glycine Transporter Inhibitors

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Description: Selective GlyT1 inhibitor

Chemical Name: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine lithium salt

Purity: ≥98%

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Biological Activity

Selective inhibitor of the glial glycine transporter (GlyT1) (pIC₅₀ values are 6.9, <4 and <3 for GlyT1, GABA transporter and Glyt2 respectively).

Technical Data

M.Wt:

373.3

Formula:

C₁₉H₁₉F₃LiNO₃

Solubility:

Soluble to 10 mM in water and to 5 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

722456-08-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord.
Bradaia et al.
J.Physiol., 2004;559:169
The time course of transmitter at glycinergic synapses onto motoneurons.
Beato
J.Neurosci., 2008;28:7412

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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