Org 25543 hydrochloride
Chemical Name: N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride
Purity: ≥99%
Biological Activity
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice.
Morita K, Motoyama N, Kitayama T et al.
J Pharmacol Exp Ther. -
The first potent and selective inhibitors of the glycine transporter type 2.
Caulfield et al.
J.Med.Chem., 2001;44:2679
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