Home / Cannabinoid R1/CB1 Modulators / Org 27569

Org 27569

Catalog #: 2957
2 Citations Datasheet / COA / SDS

Discontinued Product

2957 has been discontinued.
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Org 27569 | CAS No. 868273-06-7 | Cannabinoid R1/CB1 Modulators
1 Image
Description: Potent allosteric modulator of CB1 receptors

Chemical Name: 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Org 27569 is a potent CB1 receptor allosteric modulator (pEC50 = 8.24). Significantly increases binding of the CB1 agonist [3H]CP 55.940 (pKb = 5.67) and decreases binding of the CB1 inverse agonist [3H]SR 141716A (pKb = 5.95). Inhibits CB1 receptor antagonist efficacy in vitro (pKb = 7.57).

Technical Data

M.Wt:
409.95
Formula:
C24H28ClN3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
868273-06-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Allosteric modulation of the Cannabinoid CB1 receptor.
    Price et al.
    Mol.Pharmacol., 2005;68:1484
  2. Allosterism and the cannabinoid CB1 receptors: the shape of things to come.
    Ross
    Trends Pharmacol.Sci., 2007;28:567

Product Datasheets

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Citations for Org 27569

The citations listed below are publications that use Tocris products. Selected citations for Org 27569 include:

2 Citations: Showing 1 - 2

  1. CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.
    Authors: Baillie Et al.
    Mol Pharmacol  2013;83:322
  2. Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action.
    Authors: Cawston Et al.
    Br J Pharmacol  2013;170:893

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