Home / OX1 Receptor Antagonists / OXA (17-33)

OXA (17-33)

Catalog #: 5115
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5115/1
OXA (17-33)
1 Image
Description: Potent and selective peptide OX1 agonist

Purity: ≥95%

Product Details
Citations (3)
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Biological Activity

OXA (17-33) is a potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A (Cat. No. 1455).

Technical Data

M.Wt:
1749
Formula:
C79H125N23O22
Sequence:
YELLHGAGNHAAGILTL

(Modifications: Leu-33 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
343268-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor.
    Darker et al.
    Bioorg.Med.Chem.Lett., 2001;11:737
  2. Truncated orexin peptides: structure-activity relationship studies.
    German et al.
    Med.Chem.Lett., 2013;4:1224

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Citations for OXA (17-33)

The citations listed below are publications that use Tocris products. Selected citations for OXA (17-33) include:

3 Citations: Showing 1 - 3

  1. Properties and modulation of excitatory inputs to the locus coeruleus.
    Authors: Kelsey Et al.
    J Physiol  2022;600:4897-4916
  2. Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock.
    Authors: Hugh D Et al.
    J Neurosci  2014;34:3607-21
  3. Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain.
    Authors: Feng Et al.
    Drug Des Devel Ther  2012;12:225

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