Oxotremorine M
Chemical Name: N,N,N-Trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide
Purity: ≥98%
Biological Activity
Oxotremorine M is a muscarinic receptor agonist. Also directly potentiates NMDA-mediated ion currents.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms.
Zwart et al.
Biochem.Biophys.Res.Commun., 2017;495:481 -
The binding of agonists to brain muscarinic receptors.
Birdsall et al.
Mol.Pharmacol., 1978;14:723 -
Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system.
Kukkonen et al.
J.Pharmacol.Exp.Ther., 1996;279:593
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Citations for Oxotremorine M
The citations listed below are publications that use Tocris products. Selected citations for Oxotremorine M include:
14 Citations: Showing 1 - 10
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HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
Authors: Ahsan Raza
Nat Commun 2017;8(1):189
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Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.
Authors: Parent Et al.
Proc Natl Acad Sci U S A 2015;9:284
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Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair.
Authors: Abiraman Et al.
PLoS One 2015;35:3676
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Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
Authors: Shin Et al.
J Neurosci 2015;112:8124
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Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels.
Authors: Roberts-Crowley and Rittenhouse
Front Behav Neurosci 2015;10:e0132469
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Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors.
Authors: Wilke Et al.
Nat Commun 2014;5:5540
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Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.
Authors: Saxena Et al.
Neuron 2013;80:80
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Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors.
Authors: Deng Et al.
J Pharmacol Toxicol Methods 2013;68:323
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Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons.
Authors: Won Et al.
PLoS One 2012;7:e42602
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Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation.
Authors: Daigle and Caron
J Neurosci 2012;32:11461
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Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons.
Authors: Won Et al.
J Neurophysiol 2011;105:442
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Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
Authors: Buchanan Et al.
Neuron 2010;68:948
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The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons.
Authors: Filippov Et al.
PLoS One 2010;30:11068
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Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum.
Authors: Narushima Et al.
J Neurosci 2007;27:496
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