PA Nic
Chemical Name: (1S,2S)-1-((7-(Bis(carboxymethyl)amino)-2-oxo-2H-chromen-4-yl)methyl)-1-methyl-2-(pyridin-3-yl)pyrrolidin-1-ium ditrifluoroacetate
Purity: ≥98%
Biological Activity
PA Nic is a coumarin-caged nicotine. Releases nicotine when exposed to 390 ± 10 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at <900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M-1cm-1. Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Photoactivatable drugs for nicotinic optopharmacology.
Banala et al.
Nat.Methods, 2018;15:347 -
Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission.
Yan et al.
Cell Rep., 2018;23:2236 -
Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine.
Arvin et al.
J.Vis.Exp., 2019;143:e58873
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