PAMP-20 (human)
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Description: MRGPRX2 agonist; also non-competitive nAChR antagonist
Purity: ≥95%
Biological Activity
PAMP-20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.Technical Data
M.Wt:
2460.87
Formula:
C112H178N36O27
Sequence:
ARLDVASEFRKKWNKWALSR
(Modifications: Arg-20 = C-terminal amide)
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
150238-87-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors.
Mahata et al.
Hypertension, 1998;32:907 -
Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides.
Kamohara et al.
Biochem.Biophys.Res.Commun,, 2005;330:1146
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