Paprotrain

Key Product Details

Product Description

Paprotrain is a reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (K_i = 3.4 μM). Inhibits the basal ATPase activity of MKLP-2 (IC₅₀ = 1.35 μM). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.

Product Specifications for Paprotrain

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Paprotrain

The following data is based on the product molecular weight 245.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.08 mL	20.38 mL	40.77 mL
5 mM	0.82 mL	4.08 mL	8.15 mL
10 mM	0.41 mL	2.04 mL	4.08 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Tcherniuk Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Agnew Chem.Int.Ed.Engl. 2010 PMID: 20857469

Product Documents for Paprotrain