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PARP Enzyme High Specific Activity

Catalog #: 4668-100-01
20 Citations Datasheet / COA / SDS
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4668-100-01
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Citations (20)
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PARP Enzyme High Specific Activity Summary

Purified from E. coli containing a recombinant plasmid harboring human PARP1 gene.
 

Key Benefits

• Identification of inhibitors of PARP1 activity Quantitation of DNA Damage Investigation of PARP1 inactivation during apoptosis Western Blot Analysis

Substrate Specificity

PARP1 uses NAD+ as a substrate to catalyze poly(ADP-ribosyl)ation of target proteins involved  in  chromatin  structure  and  DNA  metabolism. PARP1 is stimulated by DNA-strand breaks and capable of auto-ribosylation.

Concentration

10 units/µl

Specifications

Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Limitations

For research use only. Not for diagnostic use.

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Citations for PARP Enzyme High Specific Activity

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

20 Citations: Showing 1 - 10
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  1. PARP1 associates with R-loops to promote their resolution and genome stability
    Authors: N Laspata, P Kaur, SY Mersaoui, D Muoio, ZS Liu, MH Bannister, HD Nguyen, C Curry, JM Pascal, GG Poirier, H Wang, JY Masson, E Fouquerel
    Nucleic Acids Research, 2023-03-21;0(0):.  2023-03-21
  2. Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension
    Authors: M Shafiq, ZR Lone, AO Abdulkaree, G Kaur, S Navya, H Singh, K Jagavelu, K Hanif
    Pulmonary pharmacology & therapeutics, 2023-02-25;0(0):102200.  2023-02-25
  3. BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
    Authors: Y Zhang, M Fang, S Li, H Xu, J Ren, L Tu, B Zuo, W Yao, G Liang
    Molecular Cancer, 2022-08-02;21(1):158.  2022-08-02
  4. Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling
    Authors: M Nagy-Pénze, Z Hajnády, Z Regdon, MÁ Demény, K Kovács, T El-Hamoly, J Maléth, P Hegyi, C Heged?s, L Virág
    Biomedicines, 2022-06-10;10(6):.  2022-06-10
  5. PARP Inhibitor Decreases Akt Phosphorylation and Induces Centrosome Amplification and Chromosomal Aneuploidy in CHO-K1 Cells
    Authors: M Tanaka, M Mushiake, J Takahashi, Y Sasaki, S Yamashita, C Ida, M Masutani, M Miwa
    International Journal of Molecular Sciences, 2022-03-23;23(7):.  2022-03-23
  6. XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair
    Authors: M Adamowicz, R Hailstone, AA Demin, E Komulainen, H Hanzlikova, J Brazina, A Gautam, SE Wells, KW Caldecott
    Nature Cell Biology, 2021-11-22;0(0):.  2021-11-22
  7. Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors
    Authors: A Hsieh, JR Pitarresi, J Lerner, G Donahue, D Hsiehchen, AK Rustgi, K Zaret
    Science Advances, 2020-12-04;6(49):.  2020-12-04
  8. PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer
    Authors: P Iglesias, M Seoane, I Golán, I Castro-Pie, M Fraga, VM Arce, JA Costoya
    Cancers (Basel), 2020-10-10;12(10):.  2020-10-10
  9. Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.
    Authors: Talhaoui I, Lebedeva N, Zarkovic G, Saint-Pierre C, Kutuzov M, Sukhanova M, Matkarimov B, Gasparutto D, Saparbaev M, Lavrik O, Ishchenko A
    Nucleic Acids Res, 2016-07-28;44(19):9279-9295.  2016-07-28
  10. The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).
    Authors: Silva A, Ryan D, Galanty Y, Low J, Vandevenne M, Jackson S, MacKay J
    J Biol Chem, 2015-11-12;291(2):924-38.  2015-11-12
  11. Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.
    Authors: Khadka P, Hsu J, Veith S, Tadokoro T, Shamanna R, Mangerich A, Croteau D, Bohr V
    Mol Cell Biol, 2015-09-21;35(23):3974-89.  2015-09-21
  12. An LRP16-containing preassembly complex contributes to NF-kappaB activation induced by DNA double-strand breaks.
    Authors: Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, Wang Y, Fu X, Luo G, Han W
    Nucleic Acids Res, 2015-03-03;43(6):3167-79.  2015-03-03
  13. Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.
    Authors: Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J
    Genes Dev, 2014-12-29;29(2):157-70.  2014-12-29
  14. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
    Authors: Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan A, Ayoub N
    Proc Natl Acad Sci U S A, 2014-02-03;111(7):E728-37.  2014-02-03
  15. Molecular tweezers with varying anions: a comparative study.
    Authors: Dutt S, Wilch C, Gersthagen T, Talbiersky P, Bravo-Rodriguez K, Hanni M, Sanchez-Garcia E, Ochsenfeld C, Klarner F, Schrader T
    J Org Chem, 2013-06-18;78(13):6721-34.  2013-06-18
  16. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
    Authors: MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J
    Nucleic Acids Res, 2012-12-28;41(3):1604-21.  2012-12-28
  17. Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1.PARP1.nucleosome intermediate.
    Authors: Gottschalk A, Trivedi R, Conaway J, Conaway R
    J Biol Chem, 2012-11-06;287(52):43527-32.  2012-11-06
  18. Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair.
    Authors: King B, Cooper K, Liu K, Hudson L
    J Biol Chem, 2012-10-04;287(47):39824-33.  2012-10-04
  19. CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells.
    Authors: Wright R, Castellano G, Bonet J, Le Dily F, Font-Mateu J, Ballare C, Nacht A, Soronellas D, Oliva B, Beato M
    Genes Dev, 2012-09-01;26(17):1972-83.  2012-09-01
  20. Homogeneous screening assay for human tankyrase.
    Authors: Narwal M, Fallarero A, Vuorela P, Lehtio L
    J Biomol Screen, 2012-02-21;17(5):593-604.  2012-02-21

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