Home / Poly(ADP-ribose) Polymerase Inhibitors / PARPYnD

PARPYnD

Catalog #: 7410 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7410/2
PARPYnD | CAS No. 2561483-27-8 | Poly(ADP-ribose) Polymerase Inhibitors
1 Image
Description: PARP inhibitor; photoaffinity probe

Chemical Name: 3-(3-Butyn-1-yl)-N-[5-cyano-6-[4-[3-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]benzoyl]-1-piperazinyl]-3-pyridinyl]-3H-diazirine-3-propanamide

Purity: ≥95%

Product Details
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

PARPYnD is a potent photoaffinity probe (AfBP) for poly(ADP-ribose) polymerase (PARP) (IC50 values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). Can be used to fluorescently label PARP1 and PARP2 in cells when an azide functionalized probe is attached via copper catalysed click-chemistry. PARPYnD enriches recombinant PARP6 spiked into cellular lysates and inhibits PARP6 in cell-free assays; does not label PARP6 in intact cells. Photocrosslinking can be performed by irradiating at 365 nm.

Technical Data

M.Wt:
613.68
Formula:
C34H31N9O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2561483-27-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PARPYnD

There are currently no reviews for this product. Be the first to review PARPYnD and earn rewards!

Have you used PARPYnD?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.