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(+)-PD 128907 hydrochloride

Catalog #: 1243
9 Citations Datasheet / COA / SDS
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1243/10
1243/50
(+)-PD 128907 hydrochloride | CAS No. 300576-59-4 | Dopamine D3 Receptor Agonists
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Description: High affinity D3 agonist (D3 ≥ D2 > D4)

Chemical Name: (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride

Purity: ≥98%

Product Details
Citations (9)
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Biological Activity

(+)-PD 128907 hydrochloride is a high affinity D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.

Technical Data

M.Wt:
285.77
Formula:
C14H19NO3.HCl
Solubility:
Soluble to 10 mM in water
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
300576-59-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Endophilin marks and controls a clathrin-independent endocytic pathway.
    Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
    Nature, 2015;517(7535):460-5.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. The behavioural and neurochemical profile of the putative DA D3 receptor agonist, (+)-PD 128907, in the rat.
    Bristow et al.
    Neuropharmacology, 1996;35:285
  4. Neurochemical and functional characterization of the preferentially selective DA D3 agonist PD 128907.
    Pugsley et al.
    J.Pharmacol.Exp.Ther., 1995;275:1355
  5. Atypical antipsychotic-like effects of the DA D3 receptor agonist (+)-PD 128907.
    Witkin et al.
    Eur.J.Pharmacol., 1998;347:R1

Product Datasheets

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Citations for (+)-PD 128907 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (+)-PD 128907 hydrochloride include:

9 Citations: Showing 1 - 9

  1. Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction.
    Authors: Shin Et al.
    Neuron  2018;97:195
  2. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
    Authors: Chai Et al.
    Neuron  2017;95:531
  3. Chronic lev. treatment alters expression and function of DA D3 receptor in the MPTP/p mouse model of Parkinson's disease.
    Authors: Cote and Kuzhikandathil
    J Neurosci  2015;585:33
  4. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
    Authors: Schulz Et al.
    Br J Pharmacol  2012;167:1480
  5. Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum.
    Authors: Marcellino Et al.
    Neurosci Lett  2008;283:26016
  6. Regulation of DA transporter function and cell surface expression by D3 DA receptors.
    Authors: Zapata Et al.
    J Biol Chem  2007;282:35842
  7. Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test.
    Authors: Basso Et al.
    Neuropsychopharmacology  2005;30:1257
  8. Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the DA D1 and D3 receptors.
    Authors: Zhang Et al.
    J Neurosci  2004;24:3344
  9. Conversion of the modulatory actions of DA on spinal reflexes from depression to facilitation in D3 receptor knock-out mice.
    Authors: Clemens and Hochman
    J Neurosci  2004;24:11337

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