PD 168077 maleate

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Endophilin marks and controls a clathrin-independent endocytic pathway.
   Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
   Nature, 2015;517(7535):460-5.
2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
3. Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor.
   Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, Lugli E, Mavilio D
   J Immunol, 2014;193(6):2792-800.
4. Topographically based search for an "Ethogram" among a series of novel D₄ DA receptor agonists and antagonists.
   Clifford and Waddington
   Neuropsychopharmacology, 2000;22:538
5. Activation of DA D₄ receptors induces synaptic translocation of Ca²⁺/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons.
   Gu et al.
   Mol.Pharmacol., 2006;69:813
6. Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective DA D₄ agonists.
   Glase et al.
   J.Med.Chem., 1997;40:1771

Product Datasheets