PD 90780
Chemical Name: 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid
Purity: ≥98%
Biological Activity
PD 90780 is a a nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA.
Colquhoun et al.
J.Pharmacol.Exp.Ther., 2004;310:505 -
Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor.
Eibl et al.
Neurochem.Int., 2012;61:1266 -
Small molecule modulation of p75 neurotrophin receptor functions.
Longo et al.
CNS Neurol.Disord.Drug Targets, 2008;7:63
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