PDD 00017238
Chemical Name: 1-[(2,4-Dimethyl-5-thiazolyl)methyl]-2,3-dihydro-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)-1H-benzimidazole-5-sulfonamide
Purity: ≥98%
Biological Activity
PDD 00017238 is a high affinity and potent PARG inhibitor (Kd = 3.09 nM; IC50 = 40 nM).Negative control PDD 00031705 (Cat. No. 7009) also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib.
James et al.
ACS Chem.Biol., 2016;11:3179
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