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PDEδ ATTEC 12C

Catalog #: 8824 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8824/5
PDEδ ATTEC 12C | Active Degraders
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Description: PDEδ autophagy-tethering compound (ATTEC) Degrader

Chemical Name: N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide

Purity: ≥98%

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Biological Activity

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC50 = 1.7 μM; Dmax = 85%; Kd = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC50 values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.

Technical Data

M.Wt:
999.54
Formula:
C41H42Br2IN7O5
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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