pep2m
Biological Activity
Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression.Control Peptide also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Role of AMPA receptor cycling in synaptic transmission and plasticity.
L?scher et al.
Neuron, 1999;24:649 -
NSF binding to GluR2 regulates synaptic transmission.
Nishimune et al.
Neuron, 1998;21:87 -
Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism.
Noel et al.
Neuron, 1999;23:365 -
Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction.
Luthi et al.
Neuron, 1999;24:389 -
Functional roles of protein interactions with AMPA and kainate receptors.
Collingridge and Isaac
Neurosci.Res., 2003;47:3
Product Datasheets
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Citation for pep2m
The citations listed below are publications that use Tocris products. Selected citations for pep2m include:
1 Citation: Showing 1 - 1
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PKM ζ maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors.
Authors: Yao Et al.
Proc Natl Acad Sci U S A 2008;28:7820
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