PF 04449913 maleate
Chemical Name: 1-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate salt
Purity: ≥98%
Biological Activity
PF 04449913 maleate is a potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells.
Fukushima et al.
Cancer Sci., 2016;107:1422 -
The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells.
Giordani et al.
Oncotarget, 2016;7:55313 -
Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened.
Munchhof et al.
ACS Med.Chem.Lett., 2011;3:106
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