PF 05089771

Tocris Bioscience | Catalog # 5931

Potent and selective Nav1.7 channel blocker
Tocris Bioscience

Key Product Details

Description

Potent and selective Nav1.7 channel blocker
View all Voltage-gated Sodium Channel Blockers »

Product Description

PF 05089771 is a potent and selective Nav1.7 channel blocker (IC50 = 8, 11 and 171 nM for mouse, human and rat Nav1.7, respectively). Exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 μM for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively). Also exhibits selectivity over a panel of 81 other ion channels, receptors, enzymes and transporters. Blocks spontaneous firing of inherited erythromelalgia (IEM)-derived iPSC sensory neurons in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 05089771

Molecular Weight

672.56

Formula

C18H12Cl2FN5O3S2.C7H8O3S

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate

CAS Number

1430806-04-4

PubChem ID

71554187

InChI Key

NVKBPDYKPNYMDR-UHFFFAOYSA-N

SMILES

ClC1=C(OC2=CC=C(Cl)C=C2C3=CNN=C3N)C=C(F)C(S(NC4=CSC=N4)(=O)=O)=C1.CC5=CC=C(S(=O)(O)=O)C=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 67.26 100

Preparing Stock Solutions for PF 05089771

The following data is based on the product molecular weight 672.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.49 mL 7.43 mL 14.87 mL
5 mM 0.30 mL 1.49 mL 2.97 mL
10 mM 0.15 mL 0.74 mL 1.49 mL
50 mM 0.03 mL 0.15 mL 0.30 mL

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Product Documents for PF 05089771

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 05089771

For research use only

Related Research Areas

Ion Channels and Regulators

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  • Study of PF 05089771's Nav1.7 blocking efficacy
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/26/2019
    The effect of PF-05089771, a selective, peripherally restricted Nav1.7 sodium channel blocker on pain due to diabetic peripheral neuropathy was investigated.
    PF 05089771 5931

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